Section 1: Diabetes in its historical and social context 1. The history of diabetes 2. The diagnosis and classification of diabetes and impaired glucose tolerance 3. Type 1 diabetes: an overview 4. Type 2 diabetes: an overview 5. Epidemiology of type 1 diabetes 6. Epidemiology of type 2 diabetes 7. Health and social costs of diabetes 8. The challenge of diabetes in the developing world Section 2: Normal metabolism 9. Normal metabolism: an overview 10. The anatomy, organization and ultrastructure of the islets of Langerhans 11. The hormonal and neural control of endocrine pancreatic function 12. The structure and phylogeny of insulin 13. The biosynthesis and secretion of insulin 14. The insulin receptor and signalling mechanisms Section 3: Pathogenesis of type 1 diabetes 15. Genetic factors in the pathogenesis of type 1 diabetes 16. Viruses in the pathogenesis of type 1 diabetes 17. Diet and other environmental factors 18. Immunology and histology of type 1 diabetes 19. Animal models of type 1 diabetes Section 4: Pathogenesis of type 2 diabetes 20. Genetic factors in the pathogenesis of type 2 diabetes 21. Obesity and nutritional factors in the pathogenesis of type 2 diabetes 22. Insulin resistance in type 2 diabetes 23. B-cell defects and pancreatic abnormalities in type 2 diabetes 24. Maturity-onset diabetes of the young 25. Animal syndromes of type 2 diabetes Section 5: Other types of diabetes 26. Drug-induced diabetes 27. Endocrine diseases and diabetes 28. Pancreatic disease and diabetes 29. Syndromes of severe insulin resistance 30. Insulinopathies and genetic syndromes and diabetes Section 6: Metabolic disturbances of diabetes 31. Metabolic disturbances in diabetes 32. Acute metabolic complications of diabetes: diabetic ketoacidosis, hyperosmolar non-ketotic syndrome and lactic acidosis 33. Hypoglycaemia in diabetes Section 7: Measurements in diabetes 34. Diabetic control and its measurement 35. Research methods in Diabetes Section 8: General management issues in diabetes 36. Diet and lifestyle modification 37. Exercise in diabetes 38. Education of the diabetic patient 39. Drugs and diabetes 40. Infection and diabetes 41. Surgery in patients with diabetes Section 9: Management of type 1 diabetes 42. Insulin pharmacology 43. Insulin treatment its complications 44. Alternative forms of insulin delivery Section 10: Management of type 2 diabetes 45. Drug treatment of type 2 diabetes Section 11: Mechanisms in chronic diabetes 46. The epidemiology of complications and the relationship to blood glucose control 47. The biochemical basis of microvascular disease Section 12: Diabetic eye disease 48. Pathogenesis of diabetic retinopathy and cataract 49. The clinical features and management of diabetic eye disease (part contents)
