Part 1 Introduction: the background - extent and nature of the disorder, Eugene S.Paykel. Part 2 Causes of depression: depression - a radical social perspective, George W.Brown; evolutionary and molecular genetic approaches to manic depression, Hugh M.D.Gurling; neuroendocrine studies of the aetiology of depression, Stuart Checkley; interactive models of depression - the evidence, Paul Bebbington and Peter McGuffin; drug-related depression - clinical and epidemiological aspects, J.Guy Edwards. Part 3 The life cycle and depression: depression in adolescence, William Parry-Jones; depression in the puerperiuma conceptual controversy, John L.Cox; depression in the elderly, Elaine Murphy. Part 4 The management of depression: cognitive treatment for depression, Mark Williams; developments in antidepressants, Stuart A.Montgomery; suicide and the management of suicide attempts, Keith Hawton; the recognition, diagnosis and acknowledgement of depressive disorder by general practitioners, Andre Tylee and Paul Freeling; the role of self-help groups in the management of depression, Judy Wilson.