Knowing that the potential for miniature mass spectrometry (MS) systems is considerable, the highly qualified authors of this book provide an overview of aspects of the technology and instruments, as well as their applications in fields such as medical diagnostics and pharmaceutical research.
The book starts by describing the scope of miniature mass spectrometry, informing readers why mass spectrometers should be miniaturized and the key elements in developing integrated system for applying MS outside traditional analytical labs. It then goes on to cover the technical development of MS miniaturization, from the mass analyser to ambient sampling ionization, details integrated systems and various fields of application. The final chapter features current exemplary miniature mass spectrometer systems available through commercial or research activities.
Intended for readers interested in miniature MS and related technology and analytical applications of mass spectrometry, which might include developers and funders of these instruments, this book can be used as supplementary reading material for undergraduate and graduate students, and help professional researchers understand the history and the future development of the field.
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Für Beruf und Forschung
Für höhere Schule und Studium
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Höhe: 234 mm
Breite: 156 mm
ISBN-13
978-1-78801-075-7 (9781788010757)
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Schweitzer Klassifikation
Zheng Ouyang received his PhD degree in analytical chemistry at the Department of Chemistry of Purdue University. He continued his academic career at Purdue and became an assistant professor in 2007 at the Weldon School of Biomedical Engineering, and was promoted to professor in 2015. He has extensive research experience in analytical instrumentation. He actively proposes and promotes the concept of miniature mass spectrometry in the world, and has made significant advances in the fields of theoretical development, key components and the overall design and applications of mass spectrometers. He has published more than 130 papers, which have been cited more than 7000 times. He also has more than 40 US patents, with half of them licensed for commercialization. He has received numerous prestigious awards, including ASMS Research Award, International Mass Spectrometry Foundation Curt Brunnee Award for distinguished contribution for mass spectrometry instrumentation and China National Science and Technology Advancement Award. In 2016, he was inducted as a fellow of the American Institute for Medical and Biological Engineering.
Xiaoyu Zhou received his PhD degree in calculation physics at the Department of Physics of Wuhan University in 2012. He became interested in MS when he was a visiting student supervised by Professor Zongxiu Nie at Institute of Chemistry Chinese Academy of Science in 2009. He then moved to Purdue University and since 2012 has been a PostDoc Research Assistant for Professor Zheng Ouyang's lab. His research focuses on the fundamentals of mass spectrometry, gas dynamic and ion trajectory simulation tools, the design of the mass analyser and the ion introduction interface, and the development of MS miniaturization techniques. He has published more than 20 papers, and contributed to 6 Chinese and 1 US patent.
Dalton Snyder received his BS degree in professional chemistry and applied mathematics at the University of Evansville in 2014. He is currently pursuing a PhD in analytical chemistry at Purdue University under the direction of advisor Graham Cooks. He has published several papers on the topics of ambient ionization mass spectrometry and frequency scanning in benchtop and commercial quadrupole ion traps as well as a review on miniature mass spectrometers. His current research interests are in extending the capabilities of single ion traps.
R Graham Cooks received his PhD in analytical chemistry at University of Natal in 1965 and at Cambridge University in 1967. He was an assistant Professor at Kansas State University in 1968, then moved to Purdue University in 1971 where he has remained as professor at chemistry since 1980. In his career he has contributed principles and novel instrumentation to the subject of tandem mass spectrometry and helped initiate desorption ionization methods. His efforts have involved elucidation of fundamental physical and chemical phenomena, new instrumentation and practically useful applications. His research group has applied mass spectrometers to on-line and point-of-care monitoring. He has graduated 129 PhD students, published 1,000 papers and he has an h-index of 88. He is among the 100 most cited chemists worldwide. He is a member of the American Academy of Arts and Sciences and of the National Academy of Sciences.
Introduction; An Overview; Why Miniaturize?; How to Miniaturize?; Important Aspects for Future Development of the Miniature MS Systems; Miniaturization of the Mass Analyser; Fundamentals; Static Analyzers; Dynamic Analyzers; Practical Considerations for Miniaturizing the Analyzers; Useful Techniques for Miniaturization; Numerical Simulation Techniques; Virtual Electrode Techniques; Digital Operation Techniques; MEMS Fabrication Techniques; QQ vs QqQ; Miniaturization of Mass Spectrometer; Pumping System; Ionization and Sampling; Ion Optical and Control Systems; Detection System; Practical Considerations for Miniaturizing Mass Spectrometer; Development of Integrated Miniature MS Systems; Sample Handling Methods; Data Interpretation; Application Fields of Miniature Mass Spectrometers; Exemplary Miniature MS Systems; Direct Air Analysis MS; GC/LC/CE-MS; Ambient MS; Subject Index