Part 1 Foundation concepts of pathophysiology: introduction; cell injury; inflammation; fever; healing; disease of immunity; neoplasia. Part 2 Systemic pathophysiology: blood disorders; haemodynamic disorders; vascular disease; cardiac pathophysiology; circulatory shock; respiratory pathophysiology; gastrointestinal pathophysiology; hepatobiliary and pancreatic pathophysiology; renal pathophysiology; fluid and electrolyte imbalances; endocrine pathophysiology; skeletal and muscular pathophysiology; reproductive pathophysiology; disorders of central nervous system development, vascular support and protection, neoplasia; disorders of automatic function, movement, sensation and mental function; seizures and epilepsy; pain and pain management; trauma.