Diagnostic Pathology: Endocrine

SECTION 1: THYROID NONNEOPLASTIC HEREDITARY/GENETIC/CONGENITAL

4 Thyroglossal Duct Cyst
Vania Nose, MD, PhD and Nicole A. Cipriani, MD
8 Ectopic Thyroid
Vania Nose, MD, PhD
12 Solid Cell Nests
Vania Nose, MD, PhD
16 Dyshormonogenetic Goiter
Vania Nose, MD, PhD

INFECTIOUS

22 Acute Thyroiditis
Vania Nose, MD, PhD

AUTOIMMUNE/INFLAMMATORY

26 Subacute/Granulomatous Thyroiditis
Vania Nose, MD, PhD
32 Palpation Thyroiditis
Vania Nose, MD, PhD and Nicole A. Cipriani, MD
34 IgG4-Related Thyroid Disease
Vania Nose, MD, PhD
38 Riedel Thyroiditis
Vania Nose, MD, PhD
44 Hashimoto Thyroiditis
Vania Nose, MD, PhD
52 Graves Disease (Diffuse Hyperplasia)
Suzana Leite, MD and Vania Nose, MD, PhD
60 Amyloid Goiter
Vania Nose, MD, PhD

REACTIVE

66 Pigments and Crystals, Thyroid
Nicole A. Cipriani, MD and Vania Nose, MD, PhD
72 Post-FNA Site Changes, Thyroid
Vania Nose, MD, PhD and Darcy A. Kerr, MD

NEOPLASTIC FOLLICULAR CELL-DERIVED NEOPLASMS

74 Thyroid Follicular Nodular Disease
Vania Nose, MD, PhD
80 Adenomatous Nodules
Vania Nose, MD, PhD and Lori A. Erickson, MD
86 Follicular Thyroid Adenoma
Vania Nose, MD, PhD and Lori A. Erickson, MD
94 Follicular Thyroid Adenoma With Papillary
Architecture
Vania Nose, MD, PhD
98 Oncocytic Thyroid Adenoma
Vania Nose, MD, PhD and Lori A. Erickson, MD
102 Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features
Vania Nose, MD, PhD and Ying-Hsia Chu, MD
112 Hyalinizing Trabecular Tumor of Thyroid
Vania Nose, MD, PhD and Nicole A. Cipriani, MD
118 Follicular Thyroid Carcinoma
Vania Nose, MD, PhD and Lori A. Erickson, MD
128 Oncocytic Thyroid Carcinoma
Ying-Hsia Chu, MD and Vania Nose, MD, PhD
132 Invasive Encapsulated Follicular Variant Papillary Thyroid Carcinoma
Vania Nose, MD, PhD and Lori A. Erickson, MD
140 Kinase Fusion-Related Thyroid Carcinomas
Ying-Hsia Chu, MD and Vania Nose, MD, PhD
148 Follicular Cell-Derived Thyroid Carcinoma, High Grade
Nicole A. Cipriani, MD and Vania Nose, MD, PhD
158 Anaplastic Thyroid Carcinoma
Vania Nose, MD, PhD and Lori A. Erickson, MD
168 Papillary Thyroid Carcinoma
Vania Nose, MD, PhD and Ying-Hsia Chu, MD
182 Classic Papillary Thyroid Carcinoma
Vania Nose, MD, PhD and Julie Guilmette, MD, FRCPC
190 Infiltrative Follicular Variant Papillary Thyroid Carcinoma
Vania Nose, MD, PhD and Lori A. Erickson, MD
194 Macrofollicular Papillary Thyroid Carcinoma
Vania Nose, MD, PhD
200 Diffuse Sclerosing Papillary Thyroid Carcinoma
Nicole A. Cipriani, MD and Vania Nose, MD, PhD
206 Oncocytic Papillary Thyroid Carcinoma
Vania Nose, MD, PhD and Peter M. Sadow, MD, PhD
210 Tall Cell Papillary Thyroid Carcinoma
Vania Nose, MD, PhD and Julie Guilmette, MD, FRCPC
218 Columnar Cell Papillary Thyroid Carcinoma
Vania Nose, MD, PhD and Lori A. Erickson, MD
222 Clear Cell Papillary Thyroid Carcinoma
Vania Nose, MD, PhD and Julie Guilmette, MD, FRCPC
224 Solid/Trabecular Papillary Thyroid Carcinoma
Vania Nose, MD, PhD and Julie Guilmette, MD, FRCPC
228 Hobnail Papillary Thyroid Carcinoma
Julie Guilmette, MD, FRCPC and Vania Nose, MD, PhD
234 Warthin-Like Papillary Thyroid Carcinoma
Vania Nose, MD, PhD

C-CELL-DERIVED TUMORS

240 C-Cell Hyperplasia
Vania Nose, MD, PhD and Adam S. Fisch, MD, PhD
246 Medullary Thyroid Carcinoma
Vania Nose, MD, PhD and Adam S. Fisch, MD, PhD

MIXED MEDULLARY AND FOLLICULAR CELL CARCINOMA

256 Mixed Medullary and Follicular Cell-Derived Thyroid Carcinoma
Vania Nose, MD, PhD and Darcy A. Kerr, MD

THYMIC TUMORS WITHIN THYROID

260 Spindle Epithelial Tumor With Thymus-Like Differentiation
Vania Nose, MD, PhD
266 Intrathyroid Thymic Carcinoma
Vania Nose, MD, PhD

SALIVARY GLAND-LIKE THYROID TUMORS

274 Mucoepidermoid Carcinoma of Thyroid
Darcy A. Kerr, MD and Vania Nose, MD, PhD
278 Secretory Carcinoma of Salivary Gland Type
Darcy A. Kerr, MD and Vania Nose, MD, PhD

HEMATOLYMPHOID TUMORS

282 Lymphoma, Thyroid
Judith Ferry, MD
288 Follicular Dendritic Cell Sarcoma, Thyroid
Vania Nose, MD, PhD and Darcy A. Kerr, MD
292 Langerhans Cell Histiocytosis, Thyroid
Vania Nose, MD, PhD and Dipti P. Sajed, MD, PhD

GERM CELL ORIGIN

296 Benign Thyroid Teratoma
Vania Nose, MD, PhD
302 Struma Ovarii, Struma Carcinoid, and Malignant Struma Ovarii
Vania Nose, MD, PhD

EMBRYONAL THYROID TUMORS

310 Thyroblastoma
Vania Nose, MD, PhD and Julie Guilmette, MD, FRCPC

MESENCHYMAL AND STROMAL TUMORS

316 Peripheral Nerve Sheath Tumor, Thyroid
Vania Nose, MD, PhD and Darcy A. Kerr, MD
320 Solitary Fibrous Tumor, Thyroid
Dipti P. Sajed, MD, PhD and Vania Nose, MD, PhD
326 Paraganglioma, Thyroid
Lori A. Erickson, MD and Vania Nose, MD, PhD
332 Leiomyoma and Leiomyosarcoma, Thyroid
Dipti P. Sajed, MD, PhD and Vania Nose, MD, PhD
336 Angiosarcoma, Thyroid
Dipti P. Sajed, MD, PhD and Vania Nose, MD, PhD
340 Primary Ewing Sarcoma, Thyroid
Dipti P. Sajed, MD, PhD and Vania Nose, MD, PhD

SECONDARY TUMORS WITHIN THYROID

344 Metastasis to Thyroid Gland
Vania Nose, MD, PhD and Darcy A. Kerr, MD

TUMORS OF UNCERTAIN HISTOGENESIS

350 Cribriform Morular Thyroid Carcinoma
Vania Nose, MD, PhD
360 Sclerosing Mucoepidermoid Carcinoma With Eosinophilia
Darcy A. Kerr, MD and Vania Nose, MD, PhD

MOLECULAR PATHOLOGY OF THYROID NEOPLASMS

366 Molecular Pathology of Thyroid Neoplasms
Vania Nose, MD, PhD and Ying-Hsia Chu, MD

PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITH CARCINOMA OF THYROID GLAND

372 Thyroid Carcinoma Protocol
Vania Nose, MD, PhD and Julie Guilmette, MD, FRCPC

SECTION 2: PARATHYROID GLAND NONNEOPLASTIC

376 Primary Multiglandular Parathyroid Disease
Lori A. Erickson, MD
386 Primary Parathyroid Clear Cell Hyperplasia
Lori A. Erickson, MD
390 Secondary Parathyroid Hyperplasia
Lori A. Erickson, MD
396 Tertiary Parathyroid Hyperplasia
Lori A. Erickson, MD
400 Chronic Parathyroiditis
Lori A. Erickson, MD

NEOPLASTIC

404 Parathyroid Adenoma
Lori A. Erickson, MD and Vania Nose, MD, PhD
412 Parathyroid Lipoadenoma
Lori A. Erickson, MD
416 Atypical Parathyroid Tumor
Vania Nose, MD, PhD and Lori A. Erickson, MD
422 Parathyroid Carcinoma
Vania Nose, MD, PhD and Lori A. Erickson, MD
432 Metastasis to Parathyroid Gland
Lori A. Erickson, MD

SECTION 3: ADRENAL GLANDS ADRENAL CORTICAL NONNEOPLASTIC

438 Adrenal Heterotopia
Arthur S. Tischler, MD
440 Adrenal Hypoplasia and Malformations
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD
444 Adrenal Cytomegaly
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD
446 Infectious Disorders, Adrenal Glands
Arthur S. Tischler, MD and Nada A. Farhat, MD, MA, MPH
450 Autoimmune Adrenalitis
Arthur S. Tischler, MD and Nada A. Farhat, MD, MA, MPH
452 Adrenal Amyloidosis
Arthur S. Tischler, MD and Nada A. Farhat, MD, MA, MPH
456 Incidental Adrenal Nodules
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD
460 Adrenal Cysts
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD

ADRENAL CORTICAL NEOPLASTIC

466 Adrenocortical Hyperplasia and Adrenocortical Nodular Disease
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD
472 Primary Pigmented Nodular Adrenocortical Disease
Vania Nose, MD, PhD
478 Nonfunctioning Adrenal Cortical Adenoma
Vania Nose, MD, PhD and Peter M. Sadow, MD, PhD
480 Aldosterone-Producing Adenoma
Vania Nose, MD, PhD and Patricia Nogueira de Sa, MD
486 Cortisol-Secreting Adrenal Cortical Adenoma
Vania Nose, MD, PhD and Peter M. Sadow, MD, PhD
492 Sex Hormone-Producing Adrenal Cortical Adenoma
Vania Nose, MD, PhD and Peter M. Sadow, MD, PhD
494 Oncocytic Adrenal Cortical Adenoma
Vania Nose, MD, PhD and Peter M. Sadow, MD, PhD
498 Adrenal Cortical Carcinoma
Vania Nose, MD, PhD and Ying-Hsia Chu, MD
510 Adrenal Cortical Neoplasms in Children
Vania Nose, MD, PhD

ADRENAL MEDULLA AND PARAGANGLIA
518 Adrenal Medullary Hyperplasia
Vania Nose, MD, PhD
522 Pheochromocytoma and Paraganglioma
Vania Nose, MD, PhD, Arthur S. Tischler, MD, and Ying-Hsia Chu, MD
534 Composite Pheochromocytoma and Composite Paraganglioma
Vania Nose, MD, PhD and Arthur S. Tischler, MD
540 Neuroblastic Tumors of Adrenal Gland
Vania Nose, MD, PhD

ADRENAL MESENCHYMAL AND STROMAL TUMORS
552 Primary Adrenal Myelolipoma
Vania Nose, MD, PhD
556 Primary Adrenal Melanoma
Vania Nose, MD, PhD
560 Primary Adrenal Benign Connective Tissue Tumor
Vania Nose, MD, PhD
562 Primary Adrenal Angiosarcoma
Vania Nose, MD, PhD
566 Primary Adrenal Leiomyosarcoma
Vania Nose, MD, PhD
570 Metastasis to Adrenal Gland
Vania Nose, MD, PhD

PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITH CARCINOMA OF ADRENAL GLAND
574 Adrenal Cortical Carcinoma Protocol
Vania Nose, MD, PhD

SECTION 4: PITUITARY GLAND
NONNEOPLASTIC
578 Hypophysitis, Pituitary Gland
M.Beatriz S. Lopes, MD, PhD
582 Hyperplasia, Pituitary Gland
M.Beatriz S. Lopes, MD, PhD
584 Sarcoidosis, Pituitary Gland
M.Beatriz S. Lopes, MD, PhD and Vania Nose, MD, PhD
588 Infarction, Pituitary Gland
M.Beatriz S. Lopes, MD, PhD
590 Sheehan Syndrome, Pituitary Gland
M.Beatriz S. Lopes, MD, PhD
592 Cystic Lesions of Sellar Region
M.Beatriz S. Lopes, MD, PhD
596 Empty Sella Syndrome
M.Beatriz S. Lopes, MD, PhD

NEOPLASTIC
ANTERIOR NEUROENDOCRINE NEOPLASMS
598 Pituitary Neuroendocrine Tumor/Adenoma
M.Beatriz S. Lopes, MD, PhD and Vania Nose, MD, PhD
604 Somatotroph PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD
608 Lactotroph PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD
612 Thyrotroph PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD
616 Plurihormonal PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD
620 Corticotroph PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD
624 Gonadotroph PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD
628 Null Cell PitNET/Adenoma
M.Beatriz S. Lopes, MD, PhD
630 Metastatic Pituitary Neuroendocrine Tumor
Vania Nose, MD, PhD and M. Beatriz S. Lopes, MD, PhD

OTHER ANTERIOR PITUITARY TUMORS
634 Adamantinomatous Craniopharyngioma
M.Beatriz S. Lopes, MD, PhD
636 Papillary Craniopharyngioma
M.Beatriz S. Lopes, MD, PhD
638 Pituitary Blastoma

POSTERIOR PITUITARY NEOPLASMS

642 Pituicytoma, Spindle Cell Oncocytoma, and Granular Cell Tumor of Sella
M.Beatriz S. Lopes, MD, PhD

NEURONAL TUMORS

646 Gangliocytoma
M.Beatriz S. Lopes, MD, PhD
650 Neuronal Cell Tumors, Pituitary
M.Beatriz S. Lopes, MD, PhD

OTHER PITUITARY TUMORS

652 Metastasis to Pituitary Gland
M.Beatriz S. Lopes, MD, PhD
654 Mesenchymal and Hematopoietic Tumors, Pituitary Gland
M.Beatriz S. Lopes, MD, PhD

PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITH PRIMARY PITUITARY TUMORS

658 Protocol for Examination of Specimens From Patients With Primary Pituitary Tumors
Vania Nose, MD, PhD and M. Beatriz S. Lopes, MD, PhD

SECTION 5: ENDOCRINE PANCREAS

664 Pancreatic Neuroendocrine Neoplasms
Vania Nose, MD, PhD

PROTOCOL FOR EXAMINATION OF SPECIMENS FROM PATIENTS WITH CARCINOMA OF ENDOCRINE PANCREAS

674 Pancreatic Neuroendocrine Carcinoma Protocol
Vania Nose, MD, PhD

SECTION 6: ENDOCRINE SKIN

678 Merkel Cell Carcinoma
Lori A. Erickson, MD

SECTION 7: FAMILIAL TUMORSYNDROMES MAJOR ENDOCRINE GLAND AFFECTED THYROID GLAND

690 DICER1 Syndrome
Vania Nose, MD, PhD and Michelle Menon Miyake, MD
700 Familial Thyroid Carcinoma
Vania Nose, MD, PhD
706 McCune-Albright Syndrome
Vania Nose, MD, PhD
712 Multiple Endocrine Neoplasia Type 2 (MEN2)
Vania Nose, MD, PhD
720 Nonsyndromic Familial Follicular Cell-Derived Thyroid Carcinoma
Vania Nose, MD, PhD
726 PTEN Hamartoma Tumor Syndromes
Vania Nose, MD, PhD
734 Syndromic Familial Follicular Cell-Derived Thyroid Carcinoma
Vania Nose, MD, PhD

PARATHYROID GLAND

742 Familial Isolated Hyperparathyroidism
Vania Nose, MD, PhD and Lori A. Erickson, MD
746 Hyperparathyroidism-Jaw Tumor Syndrome
Vania Nose, MD, PhD and Lori A. Erickson, MD
754 Multiple Endocrine Neoplasia Type 1 (MEN1)
Vania Nose, MD, PhD and Michelle Menon Miyake, MD
762 Multiple Endocrine Neoplasia Type 4 (MEN4)
Vania Nose, MD, PhD and Michelle Menon Miyake, MD

ADRENAL GLAND AND PARAGANGLIA

768 Beckwith-Wiedemann Syndrome
Patricia Nogueira de Sa, MD and Vania Nose, MD, PhD
776 Carney Complex
Vania Nose, MD, PhD
784 Hereditary Neuroblastoma
Vania Nose, MD, PhD
788 Hereditary Paraganglioma/Pheochromocytoma Syndromes
Vania Nose, MD, PhD
796 Multiple Endocrine Neoplasia Type 5,MAX-Related
Vania Nose, MD, PhD
798 Neurofibromatosis Type 1
Michelle Menon Miyake, MD and Vania Nose, MD, PhD
806 von Hippel-Lindau Syndrome
Vania Nose, MD, PhD
814 SDH-Deficient Pheochromocytoma and Paraganglioma
Vania Nose, MD, PhD and Arthur S. Tischler, MD

PANCREAS

820 Glucagon Cell Hyperplasia and Neoplasia
Vania Nose, MD, PhD
824 Hereditary and Familial Pancreatic Cancer Syndrome
Daniel C. Chung, MD and Vania Nose, MD, PhD
828 MAFA-Related Familial Insulinomatosis
Vania Nose, MD, PhD
830 Pancreatic Neuroendocrine Tumor Syndromes
842 Ectopic (Paraneoplastic) Syndromes
Lori A. Erickson, MD