This book draws together for the first time contributions from carbohydrate research in the areas of neurobiology, neuropathology, and neuropharmacology, highlighting the importance of carbohydrates in the understanding of neurobiology, the development of neuropathology and the commercialisation of neuropharmacological agents. Glycobiology is a relatively new field emerging in importance both in research institutes and industry. The chapters in this book focus on aspects of the present and future application of the study of glycobiology to brain biochemistry, from basic research on glycoconjugates to practical identification of carbohydrates in neuropathological studies and the relevance of structural studies in a pharmacological perspective.
Reihe
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Technology
Zielgruppe
Illustrationen
38 line drawings, 17 halftones
Maße
Gewicht
ISBN-13
978-0-08-042283-1 (9780080422831)
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Schweitzer Klassifikation
Contents: Preface. Glycobiology and neuropharmaceuticals (E.B. Friedman). Neurobiology. Lectins in human brain (M. Caron et al.). Gangliosides and brain development (H. Rosner). Glycoconjugates and anionic sites in the blood-brain barrier (A.W. Vorbrodt). N-CAN and Ll: role of glycoproteins of the immunoglobulin superfamily in nervous system development (M.S. Fazeli, F. Walsh). Control by glycosphingolipids of cell growth, cell adhesion, and transmembrane signaling (S. Hakomori). Glycoprotein specificity and diversity (D.R. Wing). Neuropathology. Glycolipids in Alzheimer's disease (L. Svennerholm). Lectin histochemistry of the brain cortex in Alzheimer's disease (P. Zatta et al.). The role of glycolipids in autoimmune neurological disorders (R. Yu). Extracellular matrix constituents in Alzheimer's amyloid deposits (R. Kisilevsky, I.D. Young). Carbohydrate histochemisty of amyloid plaques in Alzheimer's disease (U. Schumacher et al). Neuropharmacology. Exogenous gangliosides in neuronal repair processes: interaction with neurotrophic factors (S.D. Skaper). Brain and hyaluronic acid (P. Arslan et al.). Recent developments in the MS and NMR analysis of gangliosides (R.A. Klein, H. Egge). Chemical structure and biological properties of glycoconj'ugates (H. Wiegandt).
