Part 1 The management of prostrate cancer in the third millennium: molecular diagnostics and therapy of prostrate cancer - new avenues, J. Schalken; orchidectomy and oestrogen therapy revisited, P. Iversen; antiandrogens as monotherapy for prostrate cancer, F.H. Schroder; endocrine withdrawl syndrome and its relevance to the management of hormone refractory prostrate cancer, K. Kelly. Part 2 Therapeutic dilemmas in prostrate cancer: arguments for the long-term use of combined androgen blockade, Z. Wajsman; arguments aginst the long-term use of combined androgen blockade, U.E. Studer and R.D. Mills; therapeutic dilemmas in prostrate cancer - justification for watchful waiting, N. George; intermittent androgen suppression for prostrate cancer - rationale and clinical experience, M. Gleave et al.