Congenital adrenal hyperplasia (CAH) consists of a group of disorders of adrenal steroidogenesis. Each disorder results from an inherited deficiency of one of the several enzymes necessary for normal steroid synthesis. The different enzyme deficiencies produce characteristic patterns of hormonal abnormalities; the clinical symptoms of the different forms of CAH depend on the particular hormones that are deficient or that are produced in excess. The earliest documented description of CAH was by DeCrecchio in 1865 (DeCrecchio 1865). This Neapolitan anatomist described a cadaver having a penis with first degree hypospadias but no externally palpable gonads. Dis- section revealed a vagina, uterus, fallopian tubes, ovaries, and markedly enlarged adrenals. It is interesting that the subject suffered a confusion of sex assignment, being declared a female at birth and a male 4 years later. He conducted himself as a male sexually and socially. Since the original descrip- tion of this case, investigators have unravelled the pathophysiology of the inborn errors of steroidogenesis. 1 Steroidogenesis and Enzymatic Conversions of Adrenal Steroid Hormones A.
Steroidogenesis The adrenal synthesizes three main classes of hormones: mineralocorticoids (17-deoxy pathway), glucocorticoids (17-hydroxy pathway), and sex steroids.
Reihe
Auflage
Softcover reprint of the original 1st ed. 1984
Sprache
Verlagsort
Verlagsgruppe
Zielgruppe
Für Beruf und Forschung
Research
Illustrationen
12
12 s/w Abbildungen
X, 90 p. 12 illus.
Maße
Höhe: 244 mm
Breite: 170 mm
Dicke: 7 mm
Gewicht
ISBN-13
978-3-642-82013-7 (9783642820137)
DOI
10.1007/978-3-642-82011-3
Schweitzer Klassifikation
1 Steroidogenesis and Enzymatic Conversions of Adrenal Steroid Hormones.- A. Steroidogenesis.- B. Mechanism of Adrenal Steroid Regulation.- 2 Fetal Sexual Development.- 3 Enzyme Defects.- A. 21-Hydroxylase Deficiency.- B. 11?-Hydroxylase Deficiency.- C. 3?-Hydroxysteroid Dehydrogenase Deficiency.- D. 17a-Hydroxylase Deficiency.- E. Cholesterol Desmolase Deficiency.- F. Corticosterone Methyloxidase Deficiency.- G. 17?-Hydroxysteroid Dehydrogenase Deficiency.- H. 17,20-Lyase Deficiency.- 4 Recent Advances: The Fasciculata and Glomerulosa as Two Distinct Glands.- A. 11?-Hydroxylase Deficiency.- B. 21-Hydroxylase Deficiency.- C. 17?-Hydroxylase Deficiency.- D. 3?-Hydroxysteroid Dehydrogenase Deficiency.- 5 Treatment.- A. Endocrine Treatment.- B. Sex Assignment.- 6 Pubertal Development.- A. 21-Hydroxylase Deficiency.- B. 11?-Hydroxylase Deficiency.- C. 3?-Hydroxysteroid Dehydrogenase Deficiency.- D. 17?-Hydroxylase Deficiency.- E. Cholesterol Desmolase Deficiency.- F. Corticosterone Methyloxidase Deficiency: Types I and II.- G. 17?-Hydroxysteroid Dehydrogenase Deficiency.- H. 17,20-Lyase Deficiency.- 7 Genetics.- A. Population Studies.- B. HLA Linkage.- C. Heterozygote Detection.- D. Genetic Linkage Disequilibrium.- E. Nonclassical 21-Hydroxylase Deficiency.- F. Hormonal Standards for Genotyping 21-Hydroxylase Deficiency.- G. Allelic Variants.- H. Clinical Spectrum of 21-Hydroxylase Deficiency:.- Phenotypic Variability.- I. HLA Linkage to Other Enzyme Defects of Steroidogenesis.- J. Screening and Future Population Studies.- 8 Prenatal Diagnosis.- A. 21-Hydroxylase Deficiency.- B. 11 ?-Hydroxylase Deficiency.- C. Cholesterol Desmolase Deficiency.- Summary.- References.
