Introduction (M.T. Tsuang and J.C. Simpson). Nosology. 1. Diagnostic issues and current criteria for schizophrenia (R.C. Bland and J. Kolada). 2. Schizo-affective and schizophreniform disorders (W. Coryell). 3. Uses of structured diagnostic interviews for clinical practice and research in schizophrenia (J.E. Helzer). 4. The process of subtyping schizophrenia: strategies in the search for homogeneity (J.M. Goldstein and M.T. Tsuang). 5. Thought disorder in schizophrenia (J.T. Marengo and M. Harrow). 6. Schizophrenia spectrum disorders (L.J. Ingraham and S.S. Kety). 7. Neuroleptic response as a nosologic device (W.A. Brown and L.R. Herz). Epidemiology. 8. Basic principles of epidemiologic research in schizophrenia (E.J. Bromet, M. Davies and S.C. Schulz). 9. The use of epidemiology for risk factor research in schizophrenia: an overview and methodologic critique (W.W. Eaton, R. Day and M. Kramer). 10. Course and outcome in schizophrenia (J.F. Westermeyer and M. Harrow). 11. Mortality studies of schizophrenia (J.C. Simpson). 12. The role of psychosocial factors in the etiology, course and outcome of schizophrenia (J.P. Curran and V.A. Cirelli). 13. Schizophrenia in the elderly (B.J. Gurland). 14. Obstetric factors and perinatal injuries (T.F. McNeil). 15. Temporal factors and trends, including birth seasonality and the viral hypothesis (E. Hare). 16. Gender and schizophrenia (R.R.J. Lewine). 17. Utilization of services (T.J. Craig and B. Kovasznay). Genetics. 18. The genetics of schizophrenia: an overview (K.S. Kendler). 19. Chronicity versus vulnerability (J. Zubin). 20. The genetics of schizo-affective disorder and the schizophrenia spectrum (K.L. Rogers and G. Winokur). 21. Mathematical models of genetic transmission (S.V. Faraone, M.J. Lyons and M.T. Tsuang). 22. Genetic counselling in schizophrenia (A. Foerster and R.M. Murray). 23. High-risk studies of the etiology of schizophrenia (S.A. Mednick and L. Silverton). 24. Family history, obstetric complications and cerebral abnormality in schizophrenia (R.M. Murray, A.M. Reveley and S.W. Lewis). 25. Genetic studies of biochemical, pathophysiological and pharmacological factors in schizophrenia (P. Propping and W. Friedl). Subject index.