In view of the rapidly aging population worldwide, it is a matter of some urgency that the mechanisms of senility of the brain be determined, in areas of neurochemistry and molecular neurobiology, and that new drugs to prevent or treat brain senility be developed. This book reports on topics such as recent developments and approaches in brain senility, recent research in neurochemistry and molecular genetics on the pathogenesis of Parkinson disease and Alzheimer disease, and the development of neurotransmitter replacement. The publication provides researchers in both experimental and clinical research with the latest data to assist them in their search for the mechanism of neuronal death accompanied by aging, and the mechanism and prevention of brain senility.
In view of the rapidly aging population worldwide, it is a matter of some urgency that the mechanisms of senility of the brain be determined, in areas of neurochemistry and molecular neurobiology, and that new drugs to prevent or treat brain senility be developed. This book reports on topics such as recent developments and approaches in brain senility, recent research in neurochemistry and molecular genetics on the pathogenesis of Parkinson disease and Alzheimer disease, and the development of neurotransmitter replacement. The publication provides researchers in both experimental and clinical research with the latest data to assist them in their search for the mechanism of neuronal death accompanied by aging, and the mechanism and prevention of brain senility.
Reihe
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Technology
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Maße
ISBN-13
978-0-444-81437-1 (9780444814371)
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Schweitzer Klassifikation
Session I. Neurochemical analysis of kindled hippocampus: Autophosphorylation of calcium/calmodulin-dependent protein kinase II (Kunihiko Obata, Yayoi Nabeta, Takeshi Yamamoto). Discussion. Grafting of neuronal cells in the brain and trophic factors (Hitoo Nishino, Takeshi Hashitani, Michiko Kumazaki, Terumi Sakurai, Yukio Akiyama, Kunio Torii). Discussion. Molecular bases of immunological rejection in xenogeneic neural transplantation (Shinichi Kohsaka). Discussion. Regulation of cerebral cortical and hippocampal blood flow by cholinergic fibres originating in the nucleus basalis of Meynert and septal complex (Akio Sato, Yuko Sato). Discussion. Session II. Neurotoxin and Parkinson's disease (Yoshikuni Mizuno). Discussion. Quantitative and qualitative changes of neurotransmitters in Alzheimers's disease (Shigenobu Nakamura). Discussion. Abnormal sprouting and neurotrophic factors in Alzheimer's disease (Yoko Uchida). Discussion. Structure and expression of the human amyloid beta-protein precursor gene (Yoshiyuki Sakaki, Shun-ichi Yoshikai, Takeshi Yamada). Discussion. Author index.
