Methods in Neurodegenerative Disease Drug Discovery

Blood-Based Biomarkers for Alzheimer's Disease Diagnosis.- BACE-1 Inhibition for the Treatment of Neurodegenerative Diseases: Rationale, Assay Methodologies, and Reference Compounds.- Identification of a-Synuclein Aggregation Inhibitors via High-Throughput Screening.- TDP-43 Modulation for the Treatment of Neurodegenerative Diseases: Rationale and Assay Methodologies.- Modulation of the KEAP1-NRF2 Pathway for the Treatment of Neurodegenerative Diseases: Rationale, Assay Methodologies, and Reference Compounds.- Monoamine Oxidase Inhibition for the Treatment of Neurodegenerative Diseases: Rationale, Assay Methodologies, and Reference Compounds.- Targeting Cannabinoid Receptors against Neurodegenerative Diseases: NanoLuc Binary Technology and Proximity Ligation In Situ Assay to Evaluate Pharmacological Activity of Novel Compounds and Receptors Heteromerization.- Cholinesterase Inhibition for the Treatment of Neurodegenerative Diseases: Assay Methodologies and Reference Compounds.- Use of Calcium-Sensitive Indicators for the Determination of NMDA Receptor Activity.- Cell-Based Assays to Assess Neuroprotective Activity.- Caenorhabditis elegans Models of Neurodegenerative Diseases.- A Toolkit to Model Neurodegenerative Disease in Drosophila melanogaster.- Mouse Models of Alzheimer's Disease.- Mouse Models of Amyotrophic Lateral Sclerosis.