Sandoz Symposium on the Treatment of Parkinson's Disease, (1st), Tokyo, October 1992

Featuring contributions from outstanding researchers in the field, this publication focuses on the rather new concept of neuroprotection. Neuroprotection has its roots in earlier research on MPTP-induced parkinsonism which showed that the substantia nigra suffers selective damage. Three main topics in this innovative field have been dealt with: monoamine oxidase and its inhibitors; free radicals and their scavengers; and the role of iron in neurodegeneration. The aim is to provide a better understanding of the pathogenesis of Parkinson's disease and to ultimately find ways in which to prevent or slow the degeneration of the substantia nigra.