The study of occurrence problems in medicine. Design of the occurrence relation. Design of the study base. Design of sampling of the base. Design of information on the samples. Design of analysis. Interdependencies in design. Study protocol. Data analysis. Elements of data analysis and inference. Analysis of a single rate. Comparative analysis of two rates I: Null chi square. Comparative analysis of two rates II: Chi square function for rate difference. Comparative analysis of two rates III: Chi square function for rate ratio. Comparative analysis of two rates IV: Chi square function for odds ratio. Comparative analysis of several rates: Null chi square. Analysis of means of quantitative observations. Analysis of case-referent data. Regression analysis. Appendixes. Glossary. References. Index.