Foreword
Acknowledgements
Chapter 1 Introduction
Barry V Mendelow and Penny Keene
KEYNOTE ESSAY 1: Defining Who We Are: DNA in Forensics, Genealogy and
Human Origins
Himla Soodyall
SECTION 1 PRINCIPLES OF CELLULAR AND 13
MOLECULAR BIOLOGY
Chapter 2 Digital Concepts in Molecular Medicine
Barry V Mendelow
Chapter 3 The Anatomy and Physiology of the Genome
Marc S Weinberg, Natalie A Whalley and Michele Ramsay
Chapter 4 Molecular Cell Biology
Natalie A Whalley, Sarah Walters and Kate Hammond
Chapter 5 Genetic Variation
Silke Arndt and Anthony B Lane
Chapter 6 Genes in Development
Lillian A Ouko and Michele Ramsay
Chapter 7 Tools of Molecular Medicine
(a) Nucleic Acid Methods
Natela Rekhviashvili and Gwynneth Stevens
(b) Protein Methods
Alexio Capovilla
(c) Cellular Phenotyping and Flow Cytometry
Lesley E Scott and Debbie K Glencross
(d) Molecular Cytogenetics
Pascale Willem and Jacqueline Brown
KEYNOTE ESSAY 2: The Human Genome
Michele Ramsay
SECTION 2 MOLECULAR PATHOLOGY
Chapter 8 Genomes and the Environment:
An Overview of Molecular Pathology
Barry V Mendelow
Chapter 9 Genetics, Genomics, Health and Disease: General Considerations
Arnold L Christianson
Chapter 10 Chromosome Disorders
Sarah Walters and Nerine E Gregersen
Chapter 11 Mendelian Inheritance
Anthony B Lane
Chapter 12 Unusual Molecular Processes that Impact on Disease
Tabitha Haw and Amanda Krause
Chapter 13 Population Genetics
Anthony B Lane and Himla Soodyall
Chapter 14 Complex Multifactorial Inheritance
Zane Lombard
Molecular Medicine
Chapter 15 Molecular Basis for Phenotypic Variation
Nerine E Gregersen and Amanda Krause
Chapter 16 Medical Genetics
Nerine E Gregersen and Amanda Krause
KEYNOTE ESSAY 3: Human Cloning: Should We Go There?
Barry V Mendelow
Chapter 17 Neoplasia: General Considerations
Alan C Paterson and Leandra Cronje
Chapter 18 Oncogenes
Natalie A Whalley and Kate Hammond
Chapter 19 Mammalian DNA Repair
Alexio Capovilla
Chapter 20 Tumour Suppressor Genes and Inherited Susceptibility to Cancer
Kate Hammond
Chapter 21 Carcinoma
Alan C Paterson and Leandra Cronje
Chapter 22 Leukaemias and Lymphomas
Tracey M Wiggill, Nicole S Holland, Pascale Willem and Lindsay Earlam
Chapter 23 Molecular Approaches to the Diagnosis, Prognostication and Monitoring of Cancer
Wendy Stevens
KEYNOTE ESSAY 4: Microbes, Molecules, Maladies and Man
Adriano G Duse
Chapter 24 Molecular Basis of Infectious Diseases: General Considerations
Wendy Stevens
Chapter 25 Immunology
Wolfgang Prinz, Mieneke Smit van Dixhoorn, Elizabeth Mayne and
Ahmed A Wadee
Chapter 26 Human Immunodeficiency Virus
Wendy Stevens and Maria A Papathanasopoulos
Chapter 27 Tuberculosis
Gerrit Coetzee and Hendrik J Koornhof
Chapter 28 Malaria
Theresa L Coetzer
Chapter 29 Influenza
Barry D Schoub
Chapter 30 Oncogenic Viruses
Patrick Arbuthnot
Chapter 31 Vaccines and Immunisation
Maria A Papathanasopoulos
KEYNOTE ESSAY 5: Drugs and the 21st Century
Nicole Holland
SECTION 3 MOLECULAR THERAPEUTICS
Chapter 32 Targets for Molecular Therapy: The Biology of Haemostasis
Marion Muenster and Nanthakumarn Chetty
Chapter 33 Cellular Targets of Antiplatelet Agents
Nanthakumarn Chetty and Marion Muenster
Chapter 34 Rational Drug Design
Grant B Napier
Chapter 35 Chronic Myeloid Leukaemia
Nerina Savage
Chapter 36 Gene Therapy
Marc S Weinberg and Patrick Arbuthnot
Chapter 37 Diabetes Mellitus
Nigel J Crowther
Chapter 38 Pharmacogenetics
Chrisna Durandt, Sahle M Asfaha and Michael S Pepper
Chapter 39 Basic Molecular Biology of Blood Groups
Wolfgang Prinz
KEYNOTE ESSAY 6: Molecular Research Case Study:
Developing Novel RNA Interference-based Therapy
Patrick Arbuthnot and Marc S Weinberg
SECTION 4 RESEARCH AND THE CONTINUING EVOLUTION
OF MOLECULAR MEDICINE
Chapter 40 Approaches to Research in Molecular Medicine
Michele Ramsay
Chapter 41 Bioinformatics and Molecular Medicine
Andries J Oelofse and Michele Ramsay
Chapter 42 Personalised Medicine: Dream or Reality?
Wendy Stevens
GLOSSARY
CONTRIBUTORS' BIOGRAPHIES
SOURCE MATERIAL AND RECOMMENDED READING
PERMISSIONS AND CREDITS
INDEX
