Part 1 Splanchnic vascular anatomy and physiology: macroscopic anatomy, Adrian Marston and John Pegington; microscopic anatomy, Nicholas D.Carr; physiology, Ove Lundgren; techniques for measuring blood flow, D.Neil Granger and Karen D.Crissinger. Part 2 Pathophysiology vascular occlusion, Adrian Marston; vasospasm, J.Maurice Porter, Marc S.Sussman and Gregory B.Bulkley; vasopressor release, Keneth M.Taylor; sepsis, Mitchell P.Fink; Ischemia of liver and pancreas, Nelson J.Gurll; mechanisms of splanchnic ischemia - overview and perspective, Richard G.Fiddian-Green; hypoxia, Peter R.Kvietys and D.Neil Granger; free radicals, Matthew B.Grisham and D.Neil Granger; gastric acidity, Paul E.O'Brien; proteases, Anders Borgstrom and Ulf Haglund; bacteria, Christopher C.Kibbler; mediators of splanchnic organ injury - overview and perspective, Gregory B.Bulkley; bacterial translocation, Carol Wells et al; endotoxins, Iain McA. Ledingham and Graham Ramsay; eicosanoids, Alan M.Lefer and Haim Bitterman; myocardial depressant factors, Ulf Haglund; immunologic consequences, Carol L.Miller, Gyongyi Szabo and Jai Yan Wu; systemic mediators of splanchnic origin - overview and perspective, Ulf Haglund. Part 3 Splanchnic organ injury syndromes: stress ulceration, Richard G.Fiddian-Green; ischemic hepatitis, Selwyn M.Vickers, Robert W.Bail and Gregory B.Bulkley; acalculous cholecystitis, Ulf Haglund and Dag Arvidsson; ischemic pancreatitis, John C.Clemens, Gregory G.Bulkley and John L.Cameron; acute intestinal ischemia, John G.Mosley and Adrian Marston; focal ischemia of the small bowel, Adrian Marston; ischemic colitis, Adrian Marston; chronic intestinal ischemia, Adrian Marston. Part 4 Multiple organ failure syndromes: the gut as a "motor" in multiple organ failure, Jonathan L.Meakins; studies in splanchnic ischemia in the critically ill, Richard G.Fiddian-Green; clinical care in the ICU, Mitchell P.Fink and Richard G.Fiddian-Green; footnote, Adrian Marston.