List of Contributors. Preface. Animal Models of Type 1 Diabetes: Concordances, Discordances, Lessons (D. Zipris, et al.). The Natural History of Insulitis in Autoimmune Diabetes (H. Kolband, V. Kolb-Bachofen). New Genetic Markers (G.S. Eisenbarth). Restoring Self Tolerance in Diabetes (J.F. Bach). Tolerance Induction for Prevention of Type 1 Diabetes (P. Pozzilli, M.G. Cavallo). Clinical Trials in Pre-Diabetes: an Overview (C. Giordano, et al.). Intensive Insulin Therapy in Type 1 Diabetes (P. Brunetti, G.B. Bolli). Islet Cell Transplantation in Type-1 Diabetes (K. Federlin, et al.). New Hope from Organ and Tissue Transplantation in Diabetic Patients (A. Secchi, et al.). Insulin Resistance Versus Insulin Deficiency: Which One Comes First? The Old Question Revisited (A.J. Scheen, P.J. Lefebvre). Pathophysiological Mechanisms of Type 2 Diabetes (W. Waldhausl). Molecular Basis of Insulin Resistance (M. Federici, R. Lauro). Role of Membrane Glycoprotein Pc-1 in the Etiology of Insulin Resistance (I.D. Goldfine, et al.). Insulin and its Receptor in Growth Promotion (R. Vigneri, A. Belfiore). Lipid Metabolism in Type 2 Diabetes (G. Crepaldi, E. Manzato). Evidence-based Therapy of Type 2 Diabetes (M. Berger, I. Muhlhauser). Management of Type 2 Diabetes: Lessons from UKPDS and Other Trials (D. Leslie). From Metabolic Disorder to Diabetic Complications (A. Tiengo, et al.). Hyperglycemic Pseudohypoxia and Hypoxia in the Pathogenesis of Diabetic Complications (J.R. Williamson, Y. Ido). Hyperglycaemia and Endothelial Dysfunction (R. Giorgino). Cell-to-Cell Communication Abnormalities in the Diabetic Milieu (F. Pricci, et al.). Predictors of Cardiovascular Mortality in Type 2 Diabetes Background (M. Muggeo). The Pathophysiology of Hypertension in Diabetes Microvascular Complications (S.M. Thomas, et al.). Dystal By-pass and Endoluminal Revascularization in Diabetic Patients with Limb Threatening Ischemia (G. Ghirlanda, F. Citterio). New and Conventional Therapeutic Measures in Diabetic Complications Studies in Nephropathy, Cardiovascular Disease and Hypertension (C.E. Mogensen). Pathophysiology of Diabetic Retinopathy (M. Lorenzi, C. Gerhardinger). Pathophysiology of Diabetic Nephropathy: Role of Estrogens (G.E. Striker, et al.). Pathophysiology of Diabetic Neuropathy: a Worrying Report (J.D. Ward, S.M. Rajbhandari). Diagnosis and treatment of Diabetic Neuropathy (V. Spallone, G. Menzinger). Diabetic Complications in Pregnancy (F. Fallucca, et al.). Impact of Pancreas/Islet Transplantation on the Course of Diabetic Complications (R. Landgraf, et al.). Index
