1. Evolution and Natural Selection in Human Performance, Health and Disease, 2. Safety Factors, Reserve and Trade-offs, 3. Not Just Cousins, 4. Defining and Measuring Fatigue, 5. Morphology and Skeletal Muscle, 6. The Brain: The Emotional Aspect of Fatigue, 7. The Environment: Temperature and The Human Capacity to Resist Fatigue, 8. Energy In, Energy Out - And Fatigue, 9. Power Versus Endurance, 10. Fatigue in Disease