Contributors
Preface
VOLUME 1
Part I Introduction to Normal Bone Physiology and Pathophysiology
Chapter 1 The Bone Organ System: Form and Function
Cassandra A. Lee and Thomas A. Einhorn
Chapter 2 Osteoblast Biology
Jane B. Lian and Gary S. Stein
Chapter 3 Osteoclast Biology
F. Patrick Ross and Steven L. Teitelbaum
Chapter 4 The Biochemistry of Bone
Jayashree A. Gokhale, Pamela Gehron Robey, and Adele L. Boskey
Chapter 5 Developmental Biology of Bone
Anthony M. Reginato, Wenfang Wang, and Bjorn R. Olsen
Chapter 6 Mouse Genetics as a Tool to Study Bone Development and Physiology
Millan S. Patel and Gerard Karsenty
Chapter 7 Parathyroid Hormone and Parathyroid Hormone-Related Protein
Robert A. Nissenson
Chapter 8 Calcitonin
Ana O. Hoff, Gilbert J. Cote, and Robert F. Gagel
Chapter 9 Vitamin D: Biology, Action, and Clinical Implication
David Feldman, Peter J. Malloy, and Coleman Gross
Chapter 10 Regulation of Bone Cell Function by Estrogens
Barry S. Komm and Peter V. N. Bodine
Chapter 11 Skeletal Biology of Androgens
Kristine M. Wiren and Eric S. Orwoll
Chapter 12 Coupling of Bone Resorption and Formation during Bone Remodeling
Thomas J. Martin and Gideon A. Rodan
Chapter 13 Cytokines and Bone Remodeling
Gregory R. Mundy, Babatunde Oyajobi, Kathy Traianedes, Sarah Dallas, and Di Chen
Chapter 14 Bone Growth Factors
Xuezhong Qin, Reinhard Gysin, Subburaman Mohan, and David J. Baylink
Chapter 15 Skeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the Understanding of Osteoporosis
A. M. Parfitt
Chapter 16 Basic Biology of Bisphosphonates
H. Fleisch
Part II Structure and Biomechanics
Chapter 17 Skeletal Development: Mechanical Consequences of Growth, Aging, and Disease
Marjolein C. H. van der Meulen, Dennis R. Carter, and Gary S. Beaupre
Chapter 18 Inhibition of Osteopenia by Biophysical Intervention
Clinton T. Rubin and Kenneth J. McLeod
Chapter 19 Biomechanics of Age-Related Fractures
Mary L. Bouxsein
Part III Epidemiology and Risk Factors
Chapter 20 Introduction to Epidemiologic Methods
Jennifer L. Kelsey and MaryFran Sowers
Chapter 21 Magnitude and Impact of Osteoporosis and Fractures
L. Joseph Melton III and Cyrus Cooper
Chapter 22 Race, Ethnicity, and Osteoporosis
Marie Luz Villa, Lorene Nelson, and Dorothy Nelson
Chapter 23 Epidemiology of Osteoporosis Fractures: The European Experience
Chris de Laet and Jonathan Reeve
Chapter 24 Bone Mineral Acquisition in Utero, during Infancy, and throughout Childhood
Bonny Specker, Ran Namgung, and Reggie C. Tsang
Chapter 25 Bone Acquisition in Adolescence
Jean-Philippe Bonjour and Rene Rizzoli
Chapter 26 Genetics and Genomics of Osteoporosis
Andre G. Uitterlinden, Johannes P. T. M. van Leeuwen, and Huibert A. P. Pols
Chapter 27 Nutrition and Risk for Osteoporosis
Robert P. Heaney
Chapter 28 Physical Activity and Osteoporosis
Belinda R. Beck, Janet Shaw, and Christine M. Snow
Chapter 29 Premenopausal Reproduction and Hormonal Characteristics and Risk for Osteoporosis
MaryFran Sowers
Chapter 30 Postmenopausal Endogenous and Exogenous Hormones, Degree of Obesity, Thiazide Diuretics, and Risk of Osteoporosis
Jane A. Cauley and Loran M. Salamone
Chapter 31 The Effects of Tobacco and Alcohol Use on Bone
Ego Seeman
Chapter 32 Falls as Risk Factors for Fractures
Anne Schwartz, Elizabeth Capezuti, and Jeane Ann Grisso
Chapter 33 Assessing Fracture Risk
Charles W. Slemenda, C. Conrad Johnston, and Siu L. Hui
Chapter 34 Outcomes of Osteoporotic Fractures
Elizabeth Barrett-Conner and Gail Greendale
VOLUME 2
Part IV Pathophysiology
Chapter 35 The Nature of Osteoporosis
Robert Marcus and Sharmilla Majumder
Chapter 36 Local and Systemic Factors in the Pathogenesis of Osteoporosis
Lawrence R. Raisz
Chapter 37 Animal Models for in Vivo Experimentation in Osteoporosis Research
Donald B. Kimmel
Chapter 38 The TypeI/Type II Model for Involutional Osteoporosis: Update and Modification Based on New Observations
B. Lawrence Riggs, Sundeep Khosla, and L. Joseph Melton III
Chapter 39 Bone Remodeling Findings in Osteoporosis
Robert R. Recker and M. Janet Barger-Lux
Chapter 40 The Role of Parathyroid Hormone and Vitamin D in the Pathogenesis of Osteoporosis
John P. Bilezikian and Shonni J. Silverberg
Chapter 41 Postmenopausal Osteoporosis: How the Hormonal Changes of Menopause Cause Bone Loss
Roberto Pacifici
Chapter 42 Osteoporosis in Men: Epidemiology, Pathophysiology, and Clinical Characterization
Eric S. Orwoll and Robert F. Klein
Chapter 43 Osteoporosis in Childhood and Adolescence
Laura K. Bachrach
Chapter 44 Glucocorticoid-Induced Osteoporosis: Basic Pathological Mechanisms, Clinical Features, and Management in the New Millennium
Gary M. Leong, Jacqueline R. Center, N. Kathryn Henderson, and John A. Eisman
Chapter 45 Familial Osteoporosis
Alan L. Burshell and Steven R. Smith
Chapter 46 Immobilization Osteopenia
B. Jenny Kiratli
Chapter 47 Thyroid Hormone and the Skeleton
Daniel Baran
Chapter 48 Osteoporosis in Gastrointestinal, Pancreatic, and Hepatic Diseases
Daniel D. Bikle
Chapter 49 Primary Hyperparathyroidism and Hyperparathyroid Bone Disease
Lorraine A. Fitzpatrick and Hunter Heath III
Chapter 50 Osteogenesis Imperfecta and Other Defects of Bone Development as Occasional Causes of Adult Osteoporosis
Jay R. Shapiro
Chapter 51 Osteoporosis Secondary to Illnesses and Medications
Adina Schneider and Elizabeth Shane
Chapter 52 Transplantation Osteoporosis
Sol Epstein and Elizabeth Shane
Chapter 53 Osteoporosis Associated with Pregnancy
Lynn Kohlmeier and Robert Marcus
Chapter 54 Osteoprosis Associated with Rheumatologic Disorders
Steven R. Goldring
Chapter 55 Oral Bone Loss and Systemic Osteopenia
Marjorie K. Jeffcoat, Michael S. Reddy, and Arthur A. Decarlo
Part V Evaluation and Management
Chapter 56 Localized Osteoporosis
D. J. Schurman, W. J. Maloney, and R. L. Smith
Chapter 57 The Evaluation of the Patient with Osteoporosis or at Risk for Osteoporosis
Michael Kleerekoper
Chapter 58 Imaging of Osteoporosis
Michael Jergas and Harry K. Genant
Chapter 59 Clinical Use of Bone Densitometry
Kenneth G. Faulkner
Chapter 60 Biochemical Markers of Bone Turnover in Osteoporosis
P. Garnero and P. D. Delmas
Chapter 61 Osteoporosis and Its Nonskeletal Consequences: Their Impact on Treatment Decisions
Deborah T. Gold, Kenneth W. Lyles, Kathy M. Shipp, and Marc K. Drezner
Chapter 62 An Orthopedic Perspective of Osteoporosis
Michael H. Heggeness and Kenneth B. Mathis
Chapter 63 Clinical Use of Bone Biopsy
P. Chavassieux, M. Arlot, and P. J. Meunier
Part VI Pharmacology and Therapeutics
Chapter 64 Design Considerations for Clinical Investigations of Osteoporosis
Robert P. Heaney
Chapter 65 Development and Evaluation of New Drugs for Osteoporosis
Henry Bone
Chapter 66 Evidence-Based Decision Making in Osteoporosis
Ann B. Cranney and Gordon H. Guyatt
Chapter 67 The Role of Calcium in the Treatment of Osteoporosis
Bess Dawson-Hughes
Chapter 68 Vitamin D and Its Metabolites in the Management of Osteoporosis
Ian R. Reid
Chapter 69 Estrogens and Osteoporosis
Robert Lindsay and Felicia Cosman
Chapter 70 Selective Estrogen Receptor Modulators (SERMs)
Ethel S. Siris and Douglas B. Muchmore
Chapter 71 Phytoestrogen and Other Phytochemical Effects on Bone
Richard Prince
Chapter 72 Bisphosphonates in the Management of Postmenopausal Osteoporosis
Socrates E. Papapoulous
Chapter 73 Calcitonin
Roberto Civitelli
Chapter 74 Fluoride Therapy for Osteoporosis
K.-H. William Lau and David J. Baylink
Chapter 75 A New Perspective on Fluoride Therapy
Charles Y. C. Pak
Chapter 76 Androgens and Andogenic Progestins
Sundeep Khosla
Chapter 77 Treatment with PTH Peptides
Lis Mosekilde and Jonathan Reeve
Chapter 78 Growth Hormone and Insulin-Like Growth Factors: Potential Applications and Limitations in the Management of Osteoporosis
Christian Wuester and Clifford Rosen
Chapter 79 New Approaches to Osteoporosis Therapeutics
S. Aubrey Stoch, Michael Chorev, and Michael Rosenblatt
Index
