Peripheral consequences of nerve injury.- Electrophysiological characteristics of injured peripheral nerves.- Sodium channels and the molecular basis for pain.- Changes in DRG neurons after injury: possible involvement in the development and maintenance of neuropathic pain.- Neuroinflammation, cytokines and neuropathic pain.- Spinal cord plasticity following peripheral nerve injury.- Pharmacological plasticity associated with neuropathic pain states.- Sprouting and reorganization in the spinal cord after nerve injury.- Neuropathic pain: preclinical and clinical paradigms.- Pre-clinical nerve ligation models: behavior and electrophysiology.- Animal models of toxic and metabolic sensory neuropathies.- Role of adrenergic transmitters and receptors in nerve and tissue injury related pain.- Evaluation of neuropathic pain.- New treatment strategies for neuropathic pain.- Glutamate receptor antagonists and neuropathic pain.- Antiepileptic drugs for treatment of neuropathic pain.- Calcium channel antagonists for the treatment of pain.- Cholinergic, adenosinergic and a2 adrenergic mechanisms in chronic neuropathic pain.
