Part 1: Overview and General Principles.- 1. Impact, Diagnosis, Phenomenology, and Biology.- Part 2: The Past - from antiquity to 1970 including TCAs and MAOIs.- 2. Tricyclic Antidepressants and Monoamine Oxidase Inhibitors: Are They Too Old for a New Look?.- Part 3: The Present- 1970 to 2016.- 3. Clinical Implications of the STAR*D Trial.- 4. Pharmacogenomics and Biomarkers of Depression.- 5. Therapeutic Drug Monitoring of Antidepressants.- 6. Selective Serotonin Reuptake Inhibitors.- 7. Serotonin and Norepinephrine Reuptake Inhibitors.- 8. Neurostimulation Therapies.- 9. Current Role of Herbal and Natural Preparations.- Part 4: The future.- 10. Role of Inflammation in Depression and Treatment Implications.- 11. NMDA Antagonists for Treatment-Resistant Depression.- 12. Drug Development in Psychiatry: The Long and Winding Road from Chance Discovery to Rational Development.- 13. Other Antidepressants.- Part 5: Use of Antidepressants in Special Populations.- 14. Use of Antidepressants in Patients with Co-occurring Depression and Substance Use Disorders.- 15. Treatment of Depression in Women.- 16. Management of Late-Life Depression.- 17. The Use of Antidepressants in Bipolar Depression.
