Clinical studies of CMT spanning decades and recording the incidence of pathological alterations in the populations of India and China; the clinical neurophysiologic assessment of pathophysiologic changes in peroneal muscular atrophy; axonal and Schwann metabolism and immune factors; the molecular genetic analysis of neuropathic disease, including linkage studies on peroneal muscular atrophies; metabolic studies of CMT syndromes and experimental drug trials with gangliosides, TRH and fatty acid supplementation.