During our short time on earth, we all undergo the highly complex process of aging, and with it, we experience the many physiological symptoms. Studies of premature aging have produced a great deal of information that gives some aspects of aging a better understanding. This book explores Werner's syndrome. To some, Werner's syndrome is considered a caricature of aging, but others will find it fascinating that only one mutated human gene (WRN) can bring about a multitude of complicated phenotypes that are usually associated with aging.
Auflage
Sprache
Verlagsort
Verlagsgruppe
Springer Science+Business Media
Zielgruppe
Für Beruf und Forschung
Professional/practitioner
Illustrationen
Maße
Höhe: 241 mm
Breite: 160 mm
Dicke: 16 mm
Gewicht
ISBN-13
978-0-306-48233-5 (9780306482335)
DOI
10.1007/978-1-4419-9032-7
Schweitzer Klassifikation
1. Clinical Aspects of Werner's Syndrome: Its Natural History and the Genetics of the Disease.- 2. Biochemical Roles of RecQ Helicases.- 3. Biochemical Characterization of the Werner Syndrome DNA Helicase-Exonuclease.- 4. Proteins That Interact with the Werner Syndrome Gene Product.- 5. Sensitivity of Werner's Syndrome Cells to DNA Damaging Agents: Insights into the Biological Functions of the Werner Protein.- 6. Yeast RecQHelicases: Clues to DNA Repair, Genome Stability and Aging.- 7. Potential Function of the Werner's Syndrome Homologue in the African Clawed Frog and the Mouse.- 8. Proposed Biological Functions for the Werner Syndrome Protein in DNA Metabolism.- Replicative Senescence, Telomeres and Werner's Syndrome.
