Internationally recognized physicians and researchers review both the basics of allogeneic stem cell transplantation and recent advances in the field, particularly as they relate to antitumor effects and graft-versus-host disease They also provide unique decision-tree analyses to guide clinicians in selecting and managing their allogeneic transplant patients. The innovations discussed cover a variety of areas, ranging from stem cell mobilization in normal donors, to indications for allogeneic transplantation other than hematologic malignancies, to the use of nonmyeloablative conditioning regimens. The authors also explore new developments in the optimal selection of unrelated allogeneic grafts (e.g., matched unrelated donor, partially mismatched family member, or umbilical cord blood), the use allogeneic peripheral blood stem cell vs marrow-derived grafts for transplantation, and the kinetics of immune reconstitution after transplantation.
Reihe
Sprache
Verlagsort
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Illustrationen
38 s/w Abbildungen
38 black & white illustrations, 1 black & white halftones, 37 black & white line drawings
Maße
Höhe: 25.4 cm
Breite: 17.8 cm
Gewicht
ISBN-13
978-0-89603-979-7 (9780896039797)
DOI
10.1007/978-1-59259-333-0
Schweitzer Klassifikation
Part I. Historical Perspective
Hematopoietic Stem Cell Transplantation: A Historical Perspective
Frederick R. Appelbaum
Part II. Disease Indications: Allogeneic Transplantation
Allogeneic Hematopoietic Cell Transplantation for Adult Patients with Acute Myelogenous Leukemia
Henry C. Fung and Stephen J. Forman
Allogeneic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia
Partow Kebriaei and Wendy Stock
Chronic Myelogenous Leukemia
Edward Copelan
Allogeneic Stem Cell Transplantation for Breast Cancer
Abby B. Siegel and Linda T. Vahdat
Allogeneic Transplantation for the Treatment of Multiple Myeloma
Stefano Tarantolo and Philip J. Bierman
Non-Hodgkin's Lymphoma
Igor Espinoza-Delgado and Dan L. Longo
Part III. Allogeneic Graft Selection
Blood vs Marrow Allogeneic Stem Cell Transplantation
Daniel Anderson and Daniel Weisdorf
Haploidentical Stem Cell Transplantation
Hillard M. Lazarus and Jacob M. Rowe
Umbilical Cord Blood Transplantation
Juliet Barker and John E. Wagner
Mesenchymal Stem Cells in Allogeneic Transplantation
Omer N. Koç and Stanton L. Gerson
Cytokines in Allogeneic Stem Cell Mobilization
Ravi Vij, Randy Brown, and John F. DiPersio
Nonmyeloablative Allogeneic Transplantation
David A. Rizzieri and Nelson J. Chao
Part IV. Supportive Care in Allogeneic Transplantation
Recent Developments in Epidemiology and Management of Invasive Fungal Infections
Andreas H. Groll and Thomas J. Walsh
Immune Recovery Following Allogeneic Blood Transplantation: Mechanisms of Immune Dysfunction
James E. Talmadge
Grading and Management of Graft-vs-Host Disease
Donna Przepiorka
Posttransplant EBV-Associated Disease
Thomas G. Gross and Brett J. Loechelt
PartV. Prevention and Management of Relapse After Allogeneic Transplantation
Allogeneic Antitumor Vaccine Strategies
Ginna G. Laport and Carl H. June
Donor Leukocyte Infusions
Robert H. Collins, Jr.
Second Hematopoietic Stem Cell Transplantation for the Treatment of Graft Failure, Graft Rejection, or Relapse
Steven N. Wolff
Part VI. Preclinical Studies in Allogeneic Transplantation
The Role of T Cell Depletion in Bone Marrow Transplantation
Yair Reisner and Massimo F. Martelli
Minimal Residual Disease in Allogeneic Recipients
Jerald P. Radich
Nonhuman Primate Models of Hematopoietic Stem Cell Transplantation
Steven M. Devine and Ronald Hoffman
In Vivo Models for the Study of Graft-vs-Host Disease and Graft-vs-Tumor Effects
Kai Sun, William J. Murphy, and Lisbeth A. Welniak
Allogeneic Effector Cell Populations: Separating GVL from GVHD
Michael R. Verneris and Robert S. Negrin
Dendritic Cells: Immunobiology and Potential Use for Cancer Immunotherapy
David Avigan
Part VII. Epilogue
Epilogue, James R. Mason and Ernest Beutler
Index
