Diabetes continues to spread worldwide. Traditionally diabetes in adults has not been considered a serious life-threatening disease. This attitude needs to be changed, however, since the complications associated with the adult form of diabetes affect almost every organ system. The high morbidity and mortality of Non-Insulin-Dependent Diabetes Mellitus (NIDDM) suggest that current treatment strategies are unsatisfactory, pointing to an urgent need for new therapeutic approaches. This volume provides a comprehensive description and evaluation of recently obtained and previously unpublished data written by leading experts in the field, together with a discussion of antidiabetics under development and new approaches for the management of type 2 diabetes.
Reihe
Sprache
Verlagsort
Verlagsgruppe
Zielgruppe
Illustrationen
85
85 s/w Tabellen
80 figures, 78 tables
Maße
Höhe: 23.5 cm
Breite: 15.5 cm
Gewicht
ISBN-13
978-3-540-58990-7 (9783540589907)
DOI
10.1007/978-3-662-09127-2
Schweitzer Klassifikation
1 Introduction.- 2 Pathophysiology of Type 2 Diabetes Mellitus.- 3 Non-Pharmacological Management of Non-Insulin-Dependent Diabetes.- Section I: Sulfonylureas.- 4 Sulfonylureas and Related Compounds: Chemistry and Structure-Activity Relationships.- 5 Sulfonylureas: Physicochemical Properties, Analytical Methods of Determination and Bioavailability.- 6 Mode of Action of Sulfonylureas.- 7 Sulfonylureas: Pharmacokinetics in Animal Experiments.- 8 Toxicology of Sulfonylureas.- 9 Clinical Pharmacology of Sulfonylureas.- Section II: Biguanides.- 10 Chemistry and Structure-Activity Relationships of Biguanides.- 11 Physicochemical Properties and Analytical Methods of Determination of Biguanides.- 12 Preclinical Pharmacology of Biguanides.- 13 Toxicology of Biguanides.- 14 Clinical Pharmacology of Biguanides.- Section III: Glucosidase Inhibitors.- 15 Chemistry and Structure-Activity Relationships of Glucosidase Inhibitors.- 16 Analytical Methods of Determination of Glucosidase Inhibitors.- 17 Pharmacology of Glucosidase Inhibitors.- 18 General Pharmacology of Glucosidase Inhibitors.- 19 Pharmacokinetics and Metabolism of Glucosidase Inhibitors.- 20 Toxicology of Glucosidase Inhibitors.- 21 Clinical Pharmacology of Glucosidase Inhibitors.- 22 Clinical Evaluation of Glucosidase Inhibitors.- 23 Oral Antidiabetic Drugs in Research and Development.- 24 New Approaches for the Treatment of Diabetes Mellitus.
