Introduction; Molecular Targeted Therapy for Hepatocellular Carcinoma: Bench to Bedside: Kudo, M.; TGFBR3 Polymorphisms and Its Haplotypes Associated with Chronic Hepatitis B Virus Infection and Age of Hepatocellular Carcinoma Occurrence: Kim, J.-H.; Yu, S.J.; Park, B.-L.; Cheong, H.S.; Pasaje, C.F.A.; Bae, J.S.; Lee, H.-S.; Shin, H.D.; Kim, Y.J.; Molecular Pathogenesis of Hepatocellular Carcinoma: Altering Transforming Growth Factor-[beta] Signaling in Hepatocarcinogenesis: Yamazaki, K.; Masugi, Y.; Sakamoto, M.; Signaling Pathway and Molecular-Targeted Therapy for Hepatocellular Carcinoma: Kudo, M.; Molecularly Targeted Therapies for Hepatocellular Carcinoma: Sorafenib as a Stepping Stone: Kim, H.Y.; Park, J.-W.; mTOR Inhibitor for the Treatment of Hepatocellular Carcinoma: Kudo, M.; Future Treatment Option for Hepatocellular Carcinoma: A Focus on Brivanib: Kudo, M.; Des-[gamma]-Carboxyprothrombin May Be a Promising Biomarker to Determine the Therapeutic Efficacy of Sorafenib for Hepatocellular Carcinoma: Ueshima, K.; Kudo, M.; Takita, M.; Nagai, T.; Tatsumi, C.; Ueda, T.; Kitai, S.; Ishikawa, E.; Yada, N.; Inoue, T.; Hagiwara, S.; Minami, Y.; Chung, H.; Sakurai, T.; Oral Branched-Chain Amino Acid Granules Reduce the Incidence of Hepatocellular Carcinoma and Improve Event-Free Survival in Patients with Liver Cirrhosis: Hayaishi, S.; Chung, H.; Kudo, M.; Ishikawa, E.; Takita, M.; Ueda, T.; Kital, S.; Inoue, T.; Yada, N.; Hagiwara, S.; Minami, Y.; Ueshima, K.; Management of Patients with Hepatocellular Carcinoma and Extrahepatic Metastasis: Lee, H.-S.; Management of Hepatocellular Carcinoma in Japan: Consensus-Based Clinical Practice Guidelines Proposed by the Japan Society of Hepatology (JSH) 2010 Updated Version: Kudo, M.; Izumi, N.; Kokudo, N.; Matsui, O.; Sakamoto, M.; Nakashima, O.; Kojiro, M.; Makuuchi, M. for the HCC Expert Panel of Japan Society of Hepatology.