Excitatory amino acids, excitotoxicity and neurodegenerative disorders; excitatory amino acid receptors - multiplicity and ligand specificity of receptor subtypes; isolation and structural characterization of excitatory amino acid receptors; electrophysiological techniques for the study of excitatory amino acids in mammalian neurones in slice preparations; receptor autoradiography of excitatory amino acid receptors - basic and clinical aspects; NMDA receptors - heterogeneity and agonism; sulphur - containing excitatory amino acids; competitive NMDA receptor antagonists; ligands for NMDA receptor modulatory sites; AMPA receptor agonists - structural, conformational and stereochemical aspects; quinoxalinediones as AMPA receptor antagonists - mechanism and structure activity studies; kainic acid receptor agonists; polyamine toxins as excitatory amino acid receptor ligands; L-AP4 receptor ligands; the quisqualate metabotropic receptor coupled to phospholipase C (Qp); therapeutic opportunities in modulators of excitatory amino acid mediated neurotransmission.
