This handy reference covers all the important methods for preparing functionalized organometallic reagents of main-group and transition metals as well as lanthanides. In addition, the synthetic scope and typical synthetic procedures are reported for each preparation method. The result is a definite must-have for any synthetic chemist in academia and industry wanting to synthesize new products efficiently.
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Verlagsort
Zielgruppe
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Höhe: 244 mm
Breite: 170 mm
ISBN-13
978-3-527-33352-3 (9783527333523)
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Schweitzer Klassifikation
Paul Knochel is professor of organic chemistry at Ludwig-Maximilians-University Munich (Germany) since 1999. He has authored over 900 publications in international journals and books, as well as 40 patents. He is a recipient of the prestige Leibniz-Prize (1996), Karl-Ziegler Prize (2009), EROS (Encyclopedia of Reagents for Organic Synthesis) Best Reagent Award (2011), Gold Nagoya Medal of Organic Chemistry (2012), Herbert C. Brown Award for Creative Research in Synthetic Methods (2014), and Prix Franco-Allemand Georg Wittig - Victor Grignard (2018). His research interests include the development of new synthetic methods with organometallic reagents, new asymmetric catalysts, and natural product synthesis.
Moritz Balkenhohl is a PhD student in the group of Prof. Paul Knochel at Ludwig-Maximilians-University Munich (Germany).
Simon Grassl is a PhD student in the group of Prof. Paul Knochel at Ludwig-Maximilians-University Munich (Germany).
Johannes Harenberg is a PhD student in the group of Prof. Paul Knochel at Ludwig-Maximilians-University Munich (Germany), working in the field of continuous flow chemistry.
Maximilian Hofmayer is a master student in the group of Prof. Paul Knochel at Ludwig-Maximilians-University Munich (Germany).
Alexander Kremsmair is a PhD student in the group of Prof. Paul Knochel at Ludwig-Maximilians-University Munich (Germany).
Ferdinand Lutter is a PhD student in the group of Prof. Paul Knochel at Ludwig-Maximilians-University Munich (Germany).
Juri Skotnitzki is a PhD student in the group of Prof. Paul Knochel at Ludwig-Maximilians-University Munich (Germany).
1. Introduction: Historical Overview and Guidelines
2. General Preparation Methods of Organometallics
2.1. Generality
2.2. Starting from Organic Halides
2.3. Starting from Other Organometallics
2.4. Starting from Organic Substrates Bearing Acidic C-H Bonds
2.5. Starting from Alkynes and Alkenes
3. Preparation of Polyfunctional Organometallics
3.1. Preparation of Polyfunctional Lithium Organometallics
3.1.1. Csp3-Li Organometallics
3.1.2. Csp2-Li Organometallics
3.1.3. Csp-Li Organometallics
3.2. Preparation of Polyfunctional Magnesium Organometallics
3.2.1. Csp3-Mg Organometallics
3.2.2. Csp2-Mg Organometallics
3.2.3. Csp-Mg Organometallics
3.3. Preparation of Polyfunctional Zinc Organometallics
3.3.1. Csp3-Zn Organometallics
3.3.2. Csp2-Zn Organometallics
3.3.3. Csp-Zn Organometallics
3.4. Preparation of Polyfunctional Aluminum and Indium Organometallics
3.4.1. Polyfunctional Aluminum Organometallics
3.4.2. Polyfunctional Indium Organometallics
3.5. Preparation of Polyfunctional Transition Metal and Lanthanide Organometallics
3.6. Preparation of Polyfunctional Organometallics in Continuous Flow
3.6.1. Polyfunctional Alkali Organometallics in Continuous Flow
3.6.2. Polyfunctional Magnesium Organometallics in Continuous Flow
3.6.3. Polyfunctional Zinc Organometallics in Continuous Flow
4. Experimental Procedures
4.1. General Considerations
4.2. Detailed Example Procedures for the Preparation of Organometallic Reagents
4.3. Titration of Organometallic Reagents
