Contents ; Preface ; Overview ; 1. Galectins in Disease and Potential Therapeutic Approaches ; Anatole A. Klyosov and Peter G. Traber ; Galectin and Galectin Inhibitors: Structural Aspects ; 2. Low-Molecular Weight Inhibitors of Galectins ; Hakon Leffler and Ulf J. Nilsson ; 3. From Carbohydrate to Peptidomimetic Inhibitors of Galectins ; Kevin H. Mayo ; Galectin Extra- and Intra-Cellular Functions and ; Their Therapeutic Implications ; 4. Intracellular Galectins: Platforms for Assembly of Macromolecular ; Complexes ; John L. Wang, Kevin C. Haudek, Patricia G. Voss, Ronald J. Patterson, and ; Eric J. Arnoys ; 5. Galectins as Novel Regulators of Platelet Signaling and Function: ; Therapeutic Implications ; Gabriel A. Rabinovich and Mirta Schattner ; 6. Galectin-1 Cross-Linking of GM1 Ganglioside in Autoimmune ; Suppression ; Robert W. Ledeen, Gusheng Wu, David Bleich, Zi-Hua Lu, and Hans-Joachim Gabius ; 7. How To Build "Lean and Mean" Anti-Tumor T Cells: A Strategic View into ; the Anti-Carbohydrate Action of Fluorinated Glucosamine Analogs ; Charles J. Dimitroff ; 8. Post-Translational Modification of Galectin-3 and Its Role in Biological ; Function ; James C. Byrd, Nachman Mazurek, and Robert S. Bresalier ; Galectin Mechanisms and Therapeutic Approaches in Cancer ; 9. The Role of Galectin-3 in Malignant Melanoma ; Gordana Radosavljevic, Ivan Jovanovic, Jelena Pantic, Nada Pejnovic, ; Nebojsa Arsenijevic, Daniel K. Hsu, and Miodrag L. Lukic ; 10. Galectins as Novel Targets for the Treatment of Malignant Gliomas ; Herwig M. Strik and Matthias Ocker ; 11. Dynamic Tuning of Galectins and Their Binding Sites During Mammary ; Tumor Progression and Metastasis ; Joana T. de Oliveira and Fatima Gartner ; 12. Galectin-3C: Human Lectin for Treatment of Cancer ; Gary A. Jarvis, Leonardo Mirandola, Yu Yuefei, Everardo Cobos, ; Maurizio Chiriva-Internati, and Constance M. John ; 13. Angiostatic Cancer Therapy by Targeting Galectins in the Tumor ; Vasculature ; Iris A. Schulkens, Arjan W. Griffioen, and Victor L. Thijssen ; 14. Galectins and Pathologies: Role of Galectin-3 in the Communication ; between Leukemia Cells and the Microenvironment ; Nora Heisterkamp, Fei Fei, and John Groffen ; 15. Translational Rational for the Clinical Development of OTX-008: A Novel ; Drug That Inhibits Galectin-1 Expression in Human Cancer Models ; Eric Raymond, Lucile Astrorgue-Xerri, Maria Serova, Maria Eugenia Riveiro, and ; Sandrine Faivre ; 16. Improving the Clinical Efficacy of Cancer Vaccines by Targeting Immune ; Suppression in Human Tumors ; Nathalie Demotte, Aristotelis Antonopoulos, Jean-Francois Baurain, Gregoire Wieers, ; Nicolas Van Baren, and Pierre van der Bruggen ; 17. Targeting Galectin-3 Unveils the Complexity of Multiple Myeloma: A ; Sweet Context ; Leonardo Mirandola, Yuefei Yu, Constance M. John, Marjorie Jenkins, ; Everardo Cobos, and Maurizio Chiriva-Internati ; 18. Galectins in the Blood Circulation: Potential Therapeutic Targets of ; Cancer Metastasis ; Carrie A. Duckworth and Lu-Gang Yu ; Galectin Mechanisms and Therapeutic Approaches in ; Inflammation and Fibrosis ; 19. A Therapeutic Role for Galectins in Acute Inflammation? ; Dianne Cooper ; 20. Galectins in Immune and Inflammatory Diseases: Insights from ; Experiments with Galectin Deficient Mice ; Daniel K. Hsu, Ri-Yao Yang, Agnes Fermin, and Fu-Tong Liu ; 21. Autoimmune Disorders in Galectin-3 Deficient Mice ; Vladislav Volarevic and Miodrag L. Lukic ; 22. Galectin-3: A Central Regulator of Chronic Inflammation and Tissue ; Fibrosis ; Neil C. Henderson, Alison C. Mackinnon, Claire Rooney, and Tariq Sethi ; 23. The Role of Galectin-3 in Stellate Cell Activation and Liver Fibrosis ; Joy X. Jiang, Xiangling Chen, Hiroo Fukada, Dan K. Hsu, Fu-tong Liu, and ; Natalie J. Torok ; 24. Galectin-3 Mediated Cardiovascular Fibrogenesis: An Important Cause of ; Heart Failure and Cardiovascular Mortality ; Wouter C. Meijers and Rudolf A. de Boer ; 25. Mucins and Galectin-3 in Ocular Surface Health and Disease ; Jerome Mauris and Pablo Argueso ; 26. Role of Galectins in Wound Healing ; Noorjahan Panjwani, Ph.D. ; Editors' Biographies ; Indexes ; Author Index ; Subject Index
