Telomeres are specialised structures at ends of linear chromosomes. They are involved in a wide range of genetic phenomena ranging from novel biochemistry to a potential role in human ageing and cancer. This book covers a number of diverse subjects including: the role of telomeres in nuclear organisation; telomere DNA sequence and unusual structures formed by telomeric sequences in vitro; replication of telomere sequences by telomerase and how this relates
to various DNA sequence features; proteins that bind or interact with telomeres; the role of telomeres in programmed and spontaneous chromosome breakage; recent speculation on the relationship between telomere loss, aging and cancer; telomere position effects on replication and transcription; human telomere
structure, genome analysis and genetic disease.
This is the first book of its kind to cover this exciting and rapidly expanding field of molecular biology and genetics. It will provide an invaluable teaching tool, and introduction to the subject for newcomers to the field, and also act as an invaluable reference for established researchers.
Rezensionen / Stimmen
In The Telomere Kipling has certainly met, and possibly exceeded, his modest goal of compiling "an accessible introduction to a field full of fascinating and unique phenomena"; he has produced an incisive and captivating account with material of interest to a broad spectrum of telophiles, from spectators to central players in research . For a work of nonfiction, I found The Telomere to be a gripping read. * Forrest Spencer, Johns Hopkins University, Science, Vol. 269, September 1995 * Although there are a number of good up-to-date review articles on particular aspects of telomeres, this book represents the first attempt that I have come across to cover such a breadth of telomere topics in a comprehensive manner. The result is excellent ... a superb source of material for anybody already in the telomere field or thinking of moving into it. In summary, I think that this is an excellent piece of academic writing and I would certainly spend
GBP45.00 to own it. * Alistair Chambers, University of Nottingham, Heredity 77 (1996) * an excellent little book ... a very timely introduction to the telomere mystery ... Thoroughly recommended and cheap at the price in paperback. * Eric Reeve, University of Edinburgh, Genetical Research, Vol. 67 - 1996 *
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Maße
Höhe: 233 mm
Breite: 156 mm
Dicke: 13 mm
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ISBN-13
978-0-19-963600-6 (9780199636006)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Klassifikation
Autor*in
Beit Memorial FellowMRC Human Genetics Unit, Edinburgh
Introduction ; 1. The cytology of the telomere ; 2. Telomere structure ; 3. Telomerase ; 4. Telomere proteins ; 5. Genome rearrangements and telomeres ; 6. Human telomere loss, ageing, and cancer ; 7. Chromatin structure and position effects ; 8. Structure and maintenance of Drosophila telomeres ; 9. Telomeres and mammalian genome analysis
