In this concise, up-to-date guide to the biology of cancer the author manages to present both the basic and the clinical while retaining a simple and concise style. Following an introduction to fundamental concepts related to the clonality of the tumors and the hypermutability of the cancer cells, he continues with a description of genes involved in the process of carcinogenesis and concludes with more complex phenomena of tumor biology, such as the role of the tumor stroma and the metastatic process. A whole section on specific topics includes pharmacogenomics and viral carcinogenesis. In addition, he describes human and animal models of the disease, emphasizing their advantages and their limitations, rounding off with unifying concepts, as well as ongoing and future perspectives. The book makes good use of simple graphs to underline the notions described in the text, a feature that particularly aids comprehension.
With a foreword by Nobel laureate Andrew V. Schally.
Rezensionen / Stimmen
"...a valuable read..." (Doody's Health Services) "...an indispensable resource for all healthcare professionals involved in cancer research." (Electric Review, February/March 2007)
Auflage
Sprache
Verlagsort
Zielgruppe
Für Beruf und Forschung
Krebsforscher, Onkologen, Molekularbiologen, Genetiker
Illustrationen
64
2 s/w Tabellen, 64 s/w Abbildungen
Illustrations
Maße
Höhe: 24 cm
Breite: 17 cm
Dicke: 1.4 cm
Gewicht
ISBN-13
978-3-527-31486-7 (9783527314867)
Schweitzer Klassifikation
Hippokratis Kiaris studied biology at the University of Athens. After graduate studies at the National Hellenic Research Foundation, Athens, and the Medical School, University of Crete, he joined the Molecular Genetics and Oncology Group at the University of Liverpool. From 1998 to 2000 he was appointed research instructor at Tulane University Medical School in the group of Nobel Laureate Andrew Schally. In 2000 he took up a position at the MGH Cancer Center, Harvard Medical School, before returning to the University of Athens in 2002.
His current research focuses on the elucidation of the molecular events that contribute to breast cancer development, and to the mechanistic aspects of tumor-stroma interactions.
Autor*in
University of Athens Medical School, Greece
Introduction
BASIC ASPECTS
Some Introductory Concepts in Tumor Biology: Clonal Evolution and Autonomy Versus Non-autonomy of the Cancer Cells
Cells' Life and Death: Cell Cycle, Senescence and Apoptosis
GENES INVOLVED IN CARCINOGENESIS
Oncogenes
Tumor Supressor Genes
Genomic Instability
A Twist in the (Genetic) Tail: Cancer Epigenetics
Non-autonomous Interactions in Carcinogenesis: The Role of Tumor Stroma
Telomerase and Cellular Immortality
Tumor Angiogenesis
Metastasis
SPECIFIC TOPICS
The Tissue Context as a Determinant of the Tumor-suppressive of Oncogenetic Function of Certain Genes
Cancer Stem Cells
Determination of Therapeutic Efficacy-Pharmacogenomics
Certain Chemicals Induce Cancer: Chemical Carcinogenesis
Hormones and Cancer
Viral Oncogenesis
UNIFYING THE CONCEPTS
Co-operation of Multiple Biological Processes is needed for the Development of Full-fledged Malignancy
Carcinogenesis in Vivo: Animal Models and Basic Approaches to Generate Genetically Modified Animals
Multistage Carcinogenesis in Humans: The Colon Cancer Model
FUTURE PERSPECTIVES
Epilogue
