This volume synthesizes the most significant research at the molecular and cellular levels on the development and maintenance of the neuromuscular system and the pathogenesis of neuromuscular diseases. Leading international investigators discuss the latest findings on the control of muscle-specific gene expression, the regulatory factors that determine the muscle phenotype, the signals that lead to the formation of the neuromuscular junction, and the structures and functions of proteins expressed in differentiated muscle. Close attention is given to current research on cell transplantation and gene therapies for Duchenne muscular dystrophy and other inherited myopathies.
This volume synthesizes the most significant research at the molecular and cellular levels on the development and maintenance of the neuromuscular system and the pathogenesis of neuromuscular diseases. Leading international investigators discuss the latest findings on the control of muscle-specific gene expression, the regulatory factors that determine the muscle phenotype, the signals that lead to the formation of the neuromuscular junction, and the structures and functions of proteins expressed in differentiated muscle. Close attention is given to current research on cell transplantation and gene therapies for Duchenne muscular dystrophy and other inherited myopathies.
Reihe
Sprache
Verlagsort
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Illustrationen
12 tables, 41 line drawings, 50 halftones
Maße
Höhe: 229 mm
Breite: 152 mm
Gewicht
ISBN-13
978-0-88167-920-5 (9780881679205)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Klassifikation
Herausgeber*in
Department of Pharmacology, Stanford University School of Medicine, Stanford, California, USA
"Nautilus", a "Drosophila" member of the myogenic regulatory gene family; myogenin and the control of muscle-specific gene expression; functional properties associated with MRF4 and other members of the bHLH muscle regulatory factor family; functional domains in the muscle-specific transcription factor Myf-5; myogenesis in the mouse - the expression of regulatory and structural genes; comparative aspects of skeletal and cardiac muscle gene regulation; regulation of Avian sarcomeric alpha-actin genes by myogenic helix-loop-helix regulatory factors, serum response factors, and F-ACT1; "c-ski" expression can increase the skeletal musculature of transgenic mice, a genetic approach to cloning regulators of mammalian differentiation; the myosin light-chain 1/3 locus - a model for developmental control of skeletal muscle differentiation; developmental regulation of the chicken alkali light-chain gene expression; alternative RNA splicing in the control of gene expression in muscle and nonmuscle cells; chicken fast myosin heavy chains; multiple myogenic cell precursors and their possible role in muscle histogenesis; positional differences among adult skeletal muscle fibres; myofilament assembly in muscle development of "Caenorhabditis elegans"; molecular genetic manipulation of cardiac myosin; the role of innervation in the differentiation of early muscle fibre types in the rat; regulation of molecules at the neuromuscular junction; molecular basis of axonal growth - role of cell adhesion molecules; clustering of acetylcholine receptors by extracellular synaptic factors; the nature of mutation and the prospect for therapy in Duchenne muscular dystrophy; the mdx mouse and mdx diaphragm - implications for the pathogenesis of Duchenne muscular dystrophy; myoblast transfer into skeletal muscle - unresolved questions of new muscle formation from injected myogenic cells; tissue and cell type distribution of transcripts of the Duchenne muscular dystrophy gene; prospects for cell transplantation and gene therapy in inherited myopathies.
