Preface. Organizing committee. List of contributors. Automation in Biotechnology (I. Karube). Automated DNA sequence analysis and the human genome (W.R. McCombie, A.R. Kerlavage, A. Martin-Gallardo, J. Gocayne, M. Fitzgerald, S. Trapp, T. Onai, S. Arakawa and M. Dubnick). Automated DNA sequencing (D.A. Amorese). An automated system for sequencing of the human genome (E. Soeda, Y. Murakami, K. Nishi and I. Endo). Automated laboratory instrumentation for the preparation and analysis of biotechnology samples (J.N. Little). Possible contribution of STM to biotechnology (M. Ono). STM investigation of macromolecules (B. Michel). Handling of biological molecules and membranes in microfabricated structures (M. Washizu). Recognition and counting of cells by image processing (T. Fukuda, S. Shiotani, F. Arai, H. Asama, T. Nagamune and I. Endo). Innovative actuators for micromanipulation and microinjection in biotechnology (T. Higuchi). Application of A.C. electrical fields to the manipulation and characterisation of cells (R. Pethig). Micromechanical silicon devices applied for biological cell fusion operation (K. Sato, Y. Kawamura and S. Tanaka). Transgenesis of animals (H. Kondoh, K. Agata and K. Ozato). Automation of plant tissue culture process (Y. Miwa). Trends in automation for clonal propagation by tissue culture (J. Aitken-Christie). Robotic workcell for flexibly automated handling of young transplants (K.C. King). Environmental control and automation in micropropagation (T. Kozai). The Ruthner container system (E. Ruthner). Requirements and technologies for automated plant growth systems on space bases (T.W. Tibbitts, R.J. Bula, R.C. Morrow, R.B. Corey and D.J. Barta). Automation in space life sciences (M. Yamashita). Automated measurements from laboratory to industrial scale. A tool for better understanding of fermentation processes (J. Villadsen). Trend of automation in bio-industry (M. Hachiya).