A major process of rediscovery has taken place in the eld of Cellular Immunology over the past 12 years-subsets of T lymphocytes exist that are speci cally d- icated to regulation or as it should be more appropriately termed suppression of all aspects of immune responses. It is certainly appropriate at this time to recall some of the history that lead to the development of the concept of immune r- ulation/suppression. Shortly after the term helper T cells was coined to described lymphocytes that "helped" both humoral and cell-mediated responses, studies from thelaboratoryofthe lateProfessorRichardGershondemonstratedthatundercertain conditions, antigen recognition by T lymphocytes also resulted in the development of cells that are able to suppress immune responses. Unfortunately, research in this eld rapidly shifted from studies of the function of the suppressor T cells to studies of their soluble products that were thought to be shed or secreted T cell receptors. A number of highly complex suppressor cell pathways and cell circuits were dev- opedand werethe subjectsof morethan5,000papersduringthisera.
In 1983-1984, this eld completelycollapsed as studies called into question the existence of the I-J region of the mouse major histocompatibility complex that was thought to encode one of the major chains of the suppressor T cell factors.
Auflage
Sprache
Verlagsort
Zielgruppe
Für Beruf und Forschung
Professional/practitioner
Illustrationen
32
39 s/w Abbildungen, 32 farbige Abbildungen
XVIII, 590 p. 71 illus., 32 illus. in color.
Maße
Höhe: 241 mm
Breite: 160 mm
Dicke: 43 mm
Gewicht
ISBN-13
978-0-387-77908-9 (9780387779089)
DOI
10.1007/978-0-387-77909-6
Schweitzer Klassifikation
Immunobiology of Regulatory T Cells.- Regulatory T Cells and the Control of Auto-Immunity: From day 3 Thymectomy to FoxP3+ Regulatory T Cells.- FoxP3 and Regulatory T Cells.- Thymic and Peripheral Generation of CD4 + Foxp3 + Regulatory T Cells.- The Role of IL-2 in the Development and Peripheral Homeostasis of Naturally Occurring CD4 + CD25 + Foxp3 + Regulatory T Cells.- IL-2 Signaling and CD4+ CD25+ Regulatory T Cells.- TGF-Beta and Regulatory T Cells.- TGF-? Regulates Reciprocal Differentiation of CD4 + CD25 + Foxp3 + Regulatory T Cells and IL-17-Producing Th17 Cells from Naïve CD4 + CD25 - T Cells.- Molecular Signalling in T Regulatory Cells.- Regulatory T Cells in Disease and Clinical Application.- CD4+Foxp3+Regulatory T Cells in Immune Tolerance.- Regulatory T Cell Control of Autoimmune Diabetes and Their Potential Therapeutic Application.- CD4+CD25+ Regulatory T Cells as Adoptive Cell Therapy for Autoimmune Disease and for the Treatment of Graft-Versus-Host Disease.- Natural CD4 + CD25 + Regulatory T Cells in Regulation of Autoimmune Disease.- Multiple Sclerosis and Regulatory T Cells.- CD4+CD25+ Regulatory T Cells and TGF-Beta in Mucosal Inflammation.- Induction of Adaptive CD4+CD25+Foxp3+ Regulatory T Cell Response in Autoimmune Disease.- Regulatory T Cells in Transplantation.- Regulatory T-cells in Therapeutic Transplantation Tolerance.- CD4 + CD25 + Regulatory T Cell Therapy for the Induction of Clinical Transplantation Tolerance.- Regulatory T Cells in Allergic Disease.- Regulatory T Cells and Tumour Immunotherapy.- Regulatory T Cells in Hepatitis and Hepatocellular Carcinoma.- CD4+CD25+ Regulatory T Cells in Viral Infections.- IL-10 and TGF-?-Producing Regulatory T Cells in Infection.- Human Type 1 T Regulatory Cells.- CD8+ T Regulatory Cells inEye Derive Tolerance.- Immune Suppression by a Novel Population of CD8??+TCR??+ Regulatory T cells.- Innate Regulatory iNKT Cells.- Natural Killer T Cells Regulate the Development of Asthma.- The Development, Activation, Function and Mechanisms of Immunosuppressive Double Negative (DN) T Cells.- ?? T Cells in Immunoregulation.
