This is a new edition in the Cellular and Molecular Neurobiology series. The majority of cells in the nervous system are glial cells. During development, these cells provide growth factors that stimulate the proliferation, migration and survival of neurones and their precursors, and promote and guide axonal growth. In the mature nervous system, glial cells provide insulating myelin sheath around axons and provide metabolic and structural support for neurones. Glial cells also have a major influence on the local response to injury of central nerve tracts and the peripheral nervous system, either promoting, or inhibiting, axonal regrowth and recovery of lost function. This book provides a comprehensive, state-of-the-art overview of research into the development, function and malfunction of glial cells. It offers a compelling insight into how basic research throws light onto diseases and disorders and points the way towards treatments. Teams of internationally renowned experts, all active in research, have contributed chapters.
Reihe
Auflage
Sprache
Verlagsort
Zielgruppe
Editions-Typ
Illustrationen
8pp colour plates, numerous halftones and line figures
Maße
Höhe: 248 mm
Breite: 174 mm
Dicke: 30 mm
Gewicht
ISBN-13
978-0-19-852478-6 (9780198524786)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Klassifikation
Herausgeber*in
Professor of Developmental NeurobiologyProfessor of Developmental Neurobiology, University College London
Professor of Biology, Wolfson Institute for Biomedical ResearchProfessor of Biology, Wolfson Institute for Biomedical Research, University College London
1. Embryonic and early postnatal development of Schwann cells ; 2. Oligodendrocyte development ; 3. Developmental origins of astrocytes ; 4. Microglia in the developing and mature central nervous system ; 5. The metabolic functions of glial cells ; 6. The role of ion channels and transmitter receptors in glial cell development ; 7. Structure and formation of the node of Ranvier ; 8. Concepts in myelin sheath evolution ; 9. Myelin-specific genes and their mutations in the mouse ; 10. Control of gene expression by oligodendrocytes ; 11. Transcription factors that control Schwann cell development and myelination ; 12. Genetic analysis of gliogenesis in Drosophila ; 13. Astrocytes are dynamic participants in central nervous system development and injury response ; 14. Glial influences on axonal regeneration ; 15. Axon-Schwann cell interactions during peripheral nerve degeneration & regeneration ; 16. The molecular genetics of hereditary demyelinating neuropathies ; 17. Genetic & cellular mechanisms of Schwann cell tumour formation: neurofibromatosis type 1 and neurofibromatosis type 2 ; 18. The neuropathology of Multiple Sclerosis ; 19. Restoring CNS myelin by glial cell transplantation ; 20. Stem cells and their gliogenic potential ; 21. Glial tumours of the CNS
