The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26% overall yield in seven steps), lysergic acid (4.0% overall yield in fifteen steps), lysergol (3.6% overall yield in fifteen steps) and isolysergol (8.2% overall yield in eleven steps) have been achieved. These are more facile synthetic route than those previously reported. These findings would contribute to the development of efficient synthetic methods for biologically active compounds containing a complex structure.
Rezensionen / Stimmen
From the reviews:
"The target audience . includes practicing organic chemists with interests in synthesis, and those with specific interests in palladium-catalysed organic reactions, and as such is suited to graduate level and above. . is well-written and provides plenty of food for thought for specialists in palladium(II) chemistry . . the book also benefits from a comprehensive experimental section at the end of each chapter. . the book reflects the high quality experimental skills of the author, and provides a useful handbook for the synthetic organometallic chemist." (Edward A. Anderson, Platinum Metals Review, Vol. 56 (3), 2012)
Reihe
Auflage
Sprache
Verlagsort
Zielgruppe
Für Beruf und Forschung
Graduate
Illustrationen
Maße
Höhe: 241 mm
Breite: 160 mm
Dicke: 12 mm
Gewicht
ISBN-13
978-4-431-54042-7 (9784431540427)
DOI
10.1007/978-4-431-54043-4
Schweitzer Klassifikation
Chapter 1. Total Synthesis of Pachastrissamine (Jaspine B) .- Chapter 2. Total Synthesis of Lysergic Acid, Lysergol, and Isolysergol .- Chapter 3. Conclusions.
