1. Introduction, Ana S. Iltis, Douglas MacKay
Part 1 The Practice and Institutional Context of Human Subjects Research
2. What is Human Subjects Research?, Kirstin Borgerson
3. The Highs and Lows of Research: Exploring Value in Research Cases, Will Schupmann, Christine Grady
4. Guidelines, Codes, and Regulations, Daniel K. Nelson, David Forster
5. Independent Review, Data Safety Monitoring, and Research Oversight, Toby L. Schonfeld
6. Research Ethics Consultation, Marion Danis
7. Advocacy and Research, Rebecca Dresser
Part 2 Key Concepts and Principles of Research Ethics
8. Respect for Persons, Joseph Millum, Danielle Bromwich
9. Coercion, Exploitation, and Undue Inducement, Trisha Phillips
10. The Social Value of Research and Health Research Priority Setting, D.M. Wenner
11. Evaluating Research Risks and Potential Benefits, Annette Rid
12. Equipoise: Integrating Social Value and Equal Respect in Research with Humans, Alex John London
13. Fair Subject Selection in Clinical and Social Scientific Research, Douglas MacKay
14. Research that Engages Community and Patient Partners, Emily E. Anderson, Ryan Spellecy
15. Ancillary-Care Obligations, Henry S. Richardson
Part 3 Research Areas and Methods
16. Old and New Trial Designs: Individually Randomized Controlled Trials, Cluster Randomized Trials, Biomarker-Stratified Trials, and Multi-Arm Platform Trials, Charles Weijer, Spencer Phillips Hey
17. Comparative Effectiveness Research, Learning Health Systems, and Pragmatic Randomized Controlled Trials: The Need for Both Clinical and Research Ethics, Scott Y.H. Kim
18. Genetics and Genomics Research, Lisa Parker
19. Research on Emerging Biotechnologies, Nancy M.P. King, Christine Nero Coughlin
20. Clinical Translation, Ethics, and Policy, Jonathan Kimmelman
21. Surgical Research, Anji Wall, Guiliano Testa
22. Research during Pandemics and Epidemics, Nir Eyal
23. Public Policy Experimentation, Douglas MacKayi
24. The Ethical Challenges of Political Science Field Experiments, Scott Desposato
25. Ethics in Behavioral and Social Science Research, James DuBois, Emily Lisi
26. Sociological Research Ethics: Contributions and Controversies, Farida Fozdar, Mark Israel
27. Big Data and Internet Research, Owen Shaefer
28. Research Ethics in Citizen Science, Lisa Rasmussen
Part 4 Research Participant Populations
29. Decolonizing Research Ethics: Best Practices for the Ethical Conduct of Research Involving Indigenous Peoples, Fern Brunger, Todd Russell, Darlene Wall
30. Closing the Gap: Improving Women's Health through Research Inclusion, Anna C. Mastroianni, Leslie Meltzer Henry
31. Minoritized Racial and Ethnic Groups, Stephanie Hoover, Stuart Rennie, Al Richmond, Mysha Wynn, Melissa Green, Giselle Corbie
32. Research in Pregnancy: Frameworks for Addressing a Neglected and Complex Study Population, Margaret Olivia Little, Marisha N. Wickremsinhe, Anne Drapkin Lyerly
33. People with Disabilities in Human Subjects Research: A History of Exploitation, a Problem of Exclusion, Alicia Ouellette
34. The Ethics of Pediatric Research, Seema K. Shah
35. Research in Adults with Diminished Capacity, Neal Dickert, Emily Largent
36. Psychiatric Research Ethics, Dominic Sisti, William R. Smith
37. A Puzzling Anomaly: Decision-Making Capacity and Research on Addiction, Louis C. Charland
38. The Ethics of Studying the Origin of Sexual Orientation and Gender Identification, Timothy F. Murphy
39. Healthy Volunteers, Jill A. Fisher
40. Ethical Issues in Research Involving Employees and Students, David B. Resnik
41. International Health Research, Bridgett Pratt
42. Military Medical Research Ethics: Investigational Drugs, Clinical Trials, and Enhancement, Michael L. Gross
43. Vulnerability in Research with Prisoners, Paul P. Christopher
44. Research on the Newly Dead, Catherine M. Hammack-Aviran
45. Biomedical Research Using Nonhuman Animals: Ethics and Translational Value, Rebecca L. Walker
