CONTENTS
INTRODUCTION & GENERAL PRINCIPLES
1 Cellular and Molecular Mechanisms of Morphogenesis
. Cell proliferation: Cell cycle, differentiation, regulation
. Cell demise: Apoptosis
. Cytoskeleton/Extracellular Matrix/Cell-Matrix interactions
. Morphogenesis & Patterning
2 Comparative Gestation
. Distinctions of the Early Embryo, Embryonic and Fetal Periods of Gestation
. Species Variations Effecting Gestation Length: Companion, Domestic, Wildlife and Laboratory Animals
. Reproductive Cycles: Hormones, Estrous, Organs, Seasonal
. Fecundity: Survival Strategies, Conception Rates
DIFFERENTIATION OF GERM LAYERS
3. Gametogenesis
. Mitosis/Meiosis
. Oogenesis
. Spermatogenesis
. Veterinary Clinical Applications/Cases
4. Fertilization
. Acrosome Reaction
. Sperm-Zona Pellucida Interactions
. Gamete Fusion
. Blocks to Polyspermy
. Syngamy and Embryo Activation
. Veterinary Clinical Applications/Cases
5. Embryo Cleavage and Blastulation
. Polarity, Compaction and Cavitation
. Embryonic Disc, Primitive Streak and Formation of the Bilaminar Embryo
. Veterinary Clinical Applications/Cases
6. Gastrulation, Body Folding and Coelom Formation
. Notocord, Neural Tube and Segmentation
. Differentiation of Ectoderm, Mesoderm and Endoderm
. Body Folding, Coelom Formation and Lung Development
. Veterinary Clinical Applications/Cases
7. Development of the Peripheral Nervous System
. Spinal Cord and Motor/Sensory Innervation
. Somite Development
8. Comparative Placentation
. Extraembryonic Membranes: Amnion, Yolk Sac, Allantois, Chorion
. Placental Strategies: Choriovitelline, Chorioallantoic
. Species Variations
. Veterinary Clinical Applications/Cases
SYSTEMS DEVELOPMENT
9. Development of the Limbs
. Limb Bud Formation
. Apical Ectodermal Ridge
. Development of the Appendicular Skeleton, Musculature, Vasculature and Innervation
. Differentiation of Distal Appendages: Digit Formation
. Veterinary Clinical Applications/Cases
10. Development of the Heart
. Primitive Heart Tube Formation
. Development of Heart Chambers and Valves
. Development of the Conduction System
. Veterinary Clinical Applications/Cases
11. Development of the Vascular System
. Formation of the Aortic Arches and the Arterial System
. Development of the Vitelline, Umbilical and Cardinal Venous System
. The Coronary Vasculature
. Circulatory changes at Parturition
. Veterinary Clinical Applications/Cases
12. Development of the Gastrointestinal System
. The Enteric Canal
. Stomach, Pancreas, Liver and Spleen
. Development of Peritoneum and Formation of Mesenteries
. Rotation and Fixation of the Midgut
. Differentiation of the Large Bowel
. Septation and Differentiation of the Cloaca
. Veterinary Clinical Applications/Cases
13. Development of the Urogenital System
. Pronephros Differentiation
. Development of the Mesonephric and Metanephric Kidneys
. Urogenital Ridge and Gonad Development
. Development of the Urogentital Duct Systems and External Genitalia
. Veterinary Clinical Applications/Cases
14. Development of the Head and Neck
. Development of the Skull and Vertebrae
. Differentiation of Pharyngeal Arch Structures and Pouch Derivatives
. Development of the Palate, Tongue and Pituitary
. Development of Facial Structures
. Veterinary Clinical Applications/Cases
15. Development of the Brain and Cranial Nerves
. Regional Differentiation and Functional Relationships
. Development of the Ventricular System
. Development and Function of the Cranial Nerves
. Veterinary Clinical Applications/Cases
16. Development of the Eyes and Ears
. Formation of the Ear
. Formation of the Eye
. Veterinary Clinical Applications/Cases
17. Development of the Integumentary System
. Differentiation of the Epidermis and Dermis
. Development of Epidermal Glands including Mammary Glands
. Formation of Hair and Teeth
. Veterinary Clinical Applications/Cases
CLINICAL AND APPLIED SYSTEMS
18. Teratology
. Genetic & Congenital
. Critical Periods & Teratogenic Agents
. Maternal/Fetal Interactions
. Specie-Specific Manifestations
19. Assisted Reproductive Technologies
. Artificial Insemination and Embryo/Gamete Transfer (ET,GIFT, ZIFT, etc)
. Cryopreservation of Germplasm
. In Vitro Maturation, Fertilization and Embryo Production
. Embryo Micromanipulation: Splitting, ICSI, Transgenics, Embryonic Stem Cells/ Chimeras, Cloning
20. Applied Embryology: Veterinary and Societal Issues
. The Role of the Veterinarian
. Contemporary Issues
Additional Reading - References
Glossary
Index
