This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this area. The first part of the book covers the definition, classification, pathophysiology, pathology, biomarkers and animal models of the disease, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The last section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotide homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to the clinical applications of these experimental therapies, that are on the horizon. The book thus spans the continuum from basic science to clinical applications.
Reihe
Auflage
Softcover reprint of the original 1st ed. 2013
Sprache
Verlagsort
Verlagsgruppe
Zielgruppe
Illustrationen
10
56 farbige Abbildungen, 10 s/w Abbildungen
IX, 576 p. 66 illus., 56 illus. in color.
Maße
Höhe: 235 mm
Breite: 155 mm
Dicke: 32 mm
Gewicht
ISBN-13
978-3-662-52157-1 (9783662521571)
DOI
10.1007/978-3-642-38664-0
Schweitzer Klassifikation
