This book presents comprehensive reviews for both translational research and clinical trials on cell therapy for stroke.
Cerebral stroke is still a leading cause of death and disability. However, despite intensive research, few treatment options are available. The therapeutic potential of cell transplantation has been studied for various pathological conditions of the central nervous system (CNS) including traumatic brain injury, traumatic spinal cord injury, degenerative disease, demyelinating disease and ischemic stroke, as the injured neural tissue in the CNS has only a limited regenerative capacity.
Recently, a growing body of evidence in this field suggests that cell transplantation holds great potential as a form of stroke therapy.
The authors, who are experts in the field of neurosurgery, review and discuss optimal cell sources and various issues involved in translational research; further, they outline ongoing clinical trials in Japan.
Auflage
Softcover reprint of the original 1st ed. 2017
Sprache
Verlagsort
Zielgruppe
Illustrationen
4
11 farbige Abbildungen, 4 s/w Abbildungen
X, 156 p. 15 illus., 11 illus. in color.
Maße
Höhe: 235 mm
Breite: 155 mm
Dicke: 9 mm
Gewicht
ISBN-13
978-4-431-56766-0 (9784431567660)
DOI
10.1007/978-4-431-56059-3
Schweitzer Klassifikation
Dr. Kiyohiro Houkin, Department of Neurosurgery, Hokkaido UniversityDr. Koji Abe, Department of Neurology, Okayama University
Dr. Satoshi Kuroda, Department of Neurosurgery, University of Toyama
Part I. Optimal Cell Sources .- 1. Bone Marrow-Derived Mononuclear Cells .- 2. Mesenchymal Stem Cells / Bone Marrow Stromal Cells .- 3. Neural Stem Cells / Neuronal Progenitor Cells.- 4. iPS Cells / iN .- Part II. Translational Research.- 5. Cell Culture.- 6. Cell Dose, Timing and Route.- 7. Scaffold.- 8. Cell Tracking .- 9. Functional Bio-Imaging .- Part III. Clinical Trials .- 10. Review of Previous Clinical Trials and Guideline of Cell Therapy.- 11. Bone Marrow-Derived Mononuclear Cells.- 12. Mesenchymal Stem Cells.
