High-throughput measurements of gene expression and genetic marker data facilitate systems biologic and systems genetic data analysis strategies. Gene co-expression networks have been used to study a variety of biological systems, bridging the gap from individual genes to biologically or clinically important emergent phenotypes.
Auflage
Sprache
Verlagsort
Zielgruppe
Für Beruf und Forschung
Professional/practitioner
Illustrationen
Maße
Höhe: 241 mm
Breite: 160 mm
Dicke: 30 mm
Gewicht
ISBN-13
978-1-4419-8818-8 (9781441988188)
DOI
10.1007/978-1-4419-8819-5
Schweitzer Klassifikation
Preface.- Networks and fundamental concepts.- Approximately factorizable networks.- Different type of network concepts.- Adjacency functions and their topological effects.- Correlation and gene co-expression networks.- Geometric interpretation of correlation networks using the singular value decomposition.- Constructing networks from matrices.- Clustering Procedures and module detection.- Evaluating whether a module is preserved in another network.- Association and statistical significance measures.- Structural equation models and directed networks.- Integrated weighted correlation network analysis of mouse liver gene expression data.- Networks based on regression models and prediction methods.- Networks between categorical or discretized numeric variables.- Networks based on the joint probability distribution of random variables.- Index.
