The discovery and study of transforming growth factor-beta (TGF-beta) has a long history, and the understanding of its role in normal and abnormal biology has been revised and enlarged many times. This issue presents this exciting peptide with all its different functions. In the kidney, TGF-beta appears to be a downstream mediator of several different pathobiologic events and contributes to increased accumulation of extracellular matrix proteins in glomeruli and in the renal interstitium, and to progressive renal failure. The physiologic expression of TGF-beta, its receptor and support proteins suggest contributions to the normal function and structure of the nephron. These may include anti-inflammatory functions and physiologic regulation of renal cell turnover. Thus, TGF-beta is probably the single most important molecule in the pathophysiology of renal disease.
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Für höhere Schule und Studium
Für Beruf und Forschung
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ISBN-13
978-3-8055-6651-3 (9783805566513)
Schweitzer Klassifikation
Introduction - an Oscar for TGF-beta and its performance in the kidney; molecular and cell biology of TGF-beta; TGF-beta receptors and signalling mechanisms; mechanisms of TGF-beta-induced cell cycle arrest; role of TGF-beta in vascular development and vascular reactivity; TGF-beta in renal development and renal growth; localization of TGF-beta and its receptors in the kidney; lessons from TGF-beta transgenic mice; TGF-beta knockout and dominant-negative receptor transgenic mice; TGF-beta in glomerular disease; link between angiotensin II and TGF-beta in the kidney TGF-beta and regulation of interstitial nephritis; potential role of TGF-beta in diabetic nephropathy; TGF-beta in renal allograft rejection.
