A new perspective on brain function depends upon an understanding of the interaction and integration of excitation and inhibition. A recent surge in research activity focused on inhibitory interneurons now makes a more balanced view possible. Technological advances such as improved imaging methods, visualized patch-clamp recording, multiplex single-cell PCR, and gene-targeted deletion or knock-in mice are some of the novel tools featured in this book. This book will provide an integrated view of neuron function, operating in a balanced regime of excitation and inhibition. It is a timely contribution emphasizing how this balance is established, maintained, and modified from the molecular to system levels.
The broad spectrum of topics from molecular to cellular and system/computational neuroscience will appeal to a wide audience of advanced graduate students, post-docs, and faculty. Moreover, this book this book features active young researchers from around the world, who are currently educating the brain scientists of tomorrow.
Auflage
Softcover reprint of the original 1st ed. 2004
Sprache
Verlagsort
Zielgruppe
Für Beruf und Forschung
Research
Illustrationen
Maße
Höhe: 254 mm
Breite: 178 mm
Dicke: 17 mm
Gewicht
ISBN-13
978-1-4613-4895-5 (9781461348955)
DOI
10.1007/978-1-4615-0039-1
Schweitzer Klassifikation
Historical Overview: Search for inhibitory neurons and their function.- I. Synapses.- 1. The organization and integrative function of the post-synaptic proteome.- 2. Dynamism of postsynaptic proteins as the mechanism of synaptic plasticity.- 3. Construction, stability and dynamics of the inhibitory postsynaptic membrane.- 4. Long-term modification at visual cortical inhibitory synapses.- 5. Activity-dependent modification of cation-chloride co-transporters underlying plasticity of GABAergic transmission.- 6. Endocannabinoid-mediated modulation of excitatory and inhibitory synaptic transmission.- II. Circuits.- 7. Balanced recurrent excitation and inhibition in local cortical networks.- 8. Local circuit neurons in the frontal cortico-striatal system.- 9. Interneuron heterogeneity in neocortex.- 10. Fast spiking cells and the balance of excitation and inhibition in the neocortex.- 11. Homeostatic regulation of excitatory-inhibitory balance.- 12. Adult neurogenesis controls excitatory-inhibitory balance in the olfactory bulb.- III. Systems.- 13. GABAA receptor subtypes: memory function and neurological disorders.- 14. LTD, spike timing and somatosensory barrel cortex plasticity.- 15. Maintaining stability and promoting plasticity: context-dependent functions of inhibition.- 16. Spike timing and visual cortical plasticity.- 17. Excitatory-inhibitory balance controls critical period plasticity.
