Preface: Heng, H.H.Q.; Karyotype Heterogeneity and Unclassified Chromosomal Abnormalities: Heng, H.H.Q.; Liu, G.; Stevens, J.B.; Abdallah, B.Y.; Horne, S.D.; Ye, K.J.; Bremer, S.W.; Chowdhury, S.K.; Ye, C.J.; Clinical Impact of Somatic Mosaicism in Cases with Small Supernumerary Marker Chromosomes: Liehr, T.; Klein, E.; Mrasek, K.; Kosyakova, N.; Guilherme, R.S.; Aust, N.; Venner, C.; Weise, A.; Hamid, A.B.; Heterogeneity of Cell Death: Stevens, J.B.; Abdallah, B.Y.; Liu, G.; Horne, S.D.; Bremer, S.W.; Ye, K.J.; Huang, J.Y.; Kurkinen, M.; Ye, C.J.; Heng, H.H.Q.; Genomic Heterogeneity in Acute Leukemia: Paulsson, K.; Somatic Cell Genomics of Brain Disorders: A New Opportunity to Clarify Genetic-Environmental Interactions: Iourov, I.Y.; Vorsanova, S.G.; Yurov, Y.B.; Trisomy 21 Mosaicism: We May All Have a Touch of Down Syndrome: Hulten, M.A.; Jonasson, J.; Iwarsson, E.; Uppal, P.; Vorsanova, S.G.; Yurov, Y.B.; Iourov, I.Y.; Never in Neutral: A Systems Biology and Evolutionary Perspective on how Aneuploidy Contributes to Human Diseases: Pavelka, N.; Rancati, G.; Identifying Early Events of Gene Expression in Breast Cancer with Systems Biology Phylogenetics: Abu-Asab, M.S.; Abu-Asab, N.; Loffredo, C.A.; Clarke, R.; Amri, H.; The Hypergenome in Inheritance and Development: Sgaramella, V.; Author Index.