Modeling of Hyperphosphorylation of Protein Tau by Tau Kinases in Brain of Transgenic Mice

1. Overview of the literature 1. Protein tau and Alzheimer's disease 2. Protein tau 3. Frontotemporal dementia and parkinsonism linked to chromosome 17 (FDTP-17) Rationale and Aims 2. Materials and methods 3. Prominent anxopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human protein tau 4. Glycogen synthase kinase-3B phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice 5. Human Glycogen Synthase Kinase-3B causes microcephaly in transgenic mice 6. Co-expression of juman cdk-5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice 7. Summary/samenvatting 8. References/publications