Preface: Pahernik, S.; Introduction: Wagner, H.; Hartmann, G.; Innate Immunity and Inflammation; Innate Immunity, Inflammation and Colorectal Cancer: Wang, K.; Grivennikov, S.; Karin, M.; Immunobiology of C-Type Lectin Receptors: Roth, S.; Thomas, C.; Ruland, J.; Mechanisms of IL-1[beta] Maturation in Neutrophils: Mankan, A.K.; Hornung, V.; Innate Immunity and Transplantation; The Innate Immune System: Its Rediscovery before Toll Was Described: Land, W.G.; Messmer, K.; Innate-Adaptive Immune Responses in Organ Ischemia/Reperfusion Injury: Ji, H.; Zhai, Y.; Kupiec-Weglinski, J.W.; Tolerogenic Dendritic Cells in Transplantation: From Preclinical to Clinical Application: Moreau, A.; Cuturi, M.-C.; Innate Immunity and Intestinal Microbiota; Microbiota's Influence on Immunity: Honda, K.; Tanoue, T.; Nagano, Y.; Atarashi, K.; Inflammasomes and Mucosal Immune Response: Elinav, E.; Henao-Mejia, J.; Flavell, R.A.; Microbial Endocrinology: An Evolution-Based Shared Mechanism Determining Microbiota's Influence on Health and Disease: Lyte, M.; Innate Immunity and Disease Promotion; Standing Guard: Innate Lymphoid Cells Promote Immunity and Tissue Homeostasis at Barrier Surfaces: Monticelli, L.A.; Artis, D.; miRNAs That Shape the Innate Immune System: Regulation through Toll-Like Receptor Signaling: Curtis, A.M.; O'Neill, L.A.J.; Type 2 Diabetes and Islet Inflammation: Donath, M.Y.; The Innate Immune System in Alzheimer's Disease: Beckert, H.; Halle, A.; Role of Inflammasomes in Obesity: Dixit, V.D.; Gut-Brain Communication in the Regulation of System Metabolism: Muller, T.D.; Pfluger, P.T.; Tschop, M.H.; Drosophila and Immunity; Metabolism and Innate Immunity: FOXO Regulation of Antimicrobial Peptides in Drosophila: Loch, G.; Jentgens, E.; Bulow, M.; Zinke, I.; Mori, T.; Suzuki, S.; Takeyama, H.; Hoch, M.; Innate Signaling and Adaptive Immunity; Dendritic Cells Orchestrate Innate Immunity against Bacterial Kidney Infection: Tittel, A.P.; Heuser, C.; Garbi, N.; Kurts, C.; Speakers at the Symposium; Author and Subject Index.