This two-volume set investigates the interaction of organic compounds with various forms of life, including macromolecules, enzymes, and organelles. It provides an introduction to the Hammett equation and its applications, as well as a discussion of the design of bioactive compounds. Volume 2 includes extensive tables of approximately 17,000 partition coefficients from octanol-water and a comprehensive listing of electronic and steric parameters in the design and study of bioactive organic compounds.
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ISBN-13
978-0-8412-2991-4 (9780841229914)
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Schweitzer Klassifikation
Electronic Effects on Organic Reactions; Applications of the Hammett Equation and Its Extended Forms; Steric Effects on Organic Reactions; The Hydrophobic Parameter: Measurement and Calculation Calculation of Octanol-Water Partition Coefficients by Fragments; QSAR of Nonspecific Toxicity; QSAR of Proteins and Enzymes; QSAR in Metabolism; QSAR of Mutagenesis, Carcinogenesis, and Antitumor Drugs; QSAR of CNS Agents; Microbial QSAR; Pesticide QSAR; Notes on the Design of Bioactive Compounds
