Oncogenes, Genes and Growth Factors

Touching on virtually every area of biological science, from neurobiology to oncology and from basic research to clinical protocols, the chapters in this contributed work address every known structural relationship between growth factor, or growth factor receptor, and oncogene. The seminal observations published three years ago by Doolittle et al and Waterfield et al that there is a close structural relationship between the platelet-derived growth factor and the V-sis oncogene electrified the field. And aside from their structural relationship, it is now clear that many of the growth factors, acting on their target cells, induce the transcription of a battery of oncogenes. This volume represents the first effort to collect such material in one place. Chapters cover in detail the background information available about the factors for which relationships have been established. Other chapters offer detailed discussions of growth factor receptor genes for which relationships have not yet been observed. The information gathered here should prove invaluable to researchers in this new and rapidly advancing field.