FOUNDATIONS.- Institutional Governance of Responsible Research and Innovation.- The ETHNA System and Support Tools.- Importance and Necessity of Stakeholder Engagement.- EXPERIENCES AND LESSONS LEARNED.- Evaluation of RRI Institutionalisation Endeavours: Specificities, Drivers, Barriers, and Good Practices based on a Multi-Stakeholder Consultation and Living Lab Experiences. -Implementing RRI in a Non-Governmental Research Institute.- Implementing RRI in a Research and Innovation Ecosystem.- Developing RRI and Research Ethics at University.- ETHICAL TOOLS INTO PRACTICE.- Relevance and Challenges of Ethics Committees.- Responsible Research & Innovation Learning Facilitation.- Activities to Foster Public Engagement in Research and Innovation. Examples from the NewHoRRIzon Project.- LOOKING INTO THE FUTURE: MAIN CHALLENGES.- Gender mainstreaming in RRI: The Double Challenge.- Navigating the Future and Overcoming Challenges to Unlock Open Science.- Ethics and Development of Advanced Technology Systems in Public Administration.