Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts.
Rezensionen / Stimmen
"The authors of Regenerative Nephrology have empowered a group of the leading investigators to provide a comprehensive overview of regenerative processes in the kidney. It spans the subject from cellular physiology to models and the first clinical trials of stem cell therapy. This book fills a gap in this rapidly expanding field. It will be an invaluable reference to the specialist investigator and a useful overview for those in nephrology or regenerative medicine who wish to become fully up to date with this important subject." --Christopher S. Wilcox, MD, PhD, George E. Schreiner Chair of Nephrology,Director, Center for Hypertension, Kidney and Vascular Health, Chief, Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC, USA
"Dr. Goligorsky has assembled an outstanding group of authors for his "Regenerative Nephrology" book. The publication of this authoritative work is timely. State-of-the-art knowledge about the phylogeny, ontogeny, and mediators of tissue regeneration is discussed and is critical in pursuing the potential role of stem cells in regenerative processes. The kidney is the organ responsible for total body homeostasis, therefore focusing on regeneration in acute and chronic kidney disease is very appropriate. Moreover, Goligorsky is an internationally prominent researcher in understanding the pathophysiology of kidney disease. Regenerative Nephrology has important sections dealing with the clinical aspects of stem cell therapy including potential risks and ethical issues. I highly recommend this important book, not just for scientists studying the kidney, but for all biomedical scientists, as the dawn of stem cell therapy in humans is emerging for many organs." --Robert W. Schrier, MD, Professor of Medicine, University of Colorado, School of Medicine, Denver, CO, USA
"With this book, Dr Goligorsky, along with his impressive collection of highly prominent authors, has certainly succeeded in achieving the goal of bringing an up-to-date review of the basic research of regenerative nephrology and its promising clinical applications to the attention of the interested reader. This is a truly international book; although the majority of the outstanding faculty is North American, excellent contributions have been written by Japanese, Australian and European authors.... This book is not only of interest to the basic expert investigator. Also, the interested teacher or clinician who wants to catch a glimpse of what will become possible in the near future in the treatment of a whole range of acute and chronic kidney diseases with these fascinating new tools will find this book a must.... Dr Goligorsky and his contributors have done a great service to most of us 'non-experts' by summarizing, in a brilliant manner, the recent advances in this field." --NDT Plus
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science Publishing Co Inc
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Medical and pharmaceutical researchers in nephrology and related renal diseases; fellows and academic clinicians in nephrology; biomedical researchers who work with stem cells.
Maße
Höhe: 276 mm
Breite: 216 mm
Gewicht
ISBN-13
978-0-12-380928-5 (9780123809285)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Klassifikation
Michael S. Goligorsky, MD. PhD, holds the Alvin I. Goodman Chair in Nephrology, and is Professor of Medicine, Pharmacology and Physiology and Director of Renal Research Institute at the New York Medical College, Touro University. Dr. Goligorsky serves as an Associate Editor for Am J Pathology and is a member of the Association of American Physicians (elected 2002). His research interests include: the mechanisms of endothelial dysfunction as a harbinger of diabetic, and hypertensive vascular damage; stress-induced premature senescence of endothelial cells and the role of lysosomal dysfunction in this process; mechanisms of functional incompetence of endothelial cells in chronic kidney disease; and mechanisms of alarm signaling by an ischemic kidney.
Herausgeber*in
Alvin I. Goodman Chair in Nephrology, Professor of Medicine, Pharmacology and Physiology, Academic Chief of Renal Division, and Director of Renal Research Institute, New York Medical College, NY, USA
PHYLOGENY AND ONTOGENY OF TISSUE REGENERATION
1. Glomerulogenesis and de novo nephrogenesis in medaka fish - evolutionary approach
Yuko Wakamatsu and Hisashi Hashimoto
2. Renal Organogenesis: Growing a replacement kidney in situ from transplanted renal primordia
Marc R. Hammerman
3. Use of Genetic Mouse Models to study Kidney Regeneration
Akio Kobayashi and Jeremy S. Duffield
MEDIATORS OF REGENERATION
4. Endogenous Anti-Inflammatory and Pro-Resolving Lipid Mediators in Renal Disease
Charles N. Serhan and Catherine Godson
5. Tissue protection and regeneration aided by erythropoietin and erythropoietin-derived peptides
Danilo Fliser
6. Mast cells in kidney regeneration
Eric Daugas, Walid Beghdadi and Ulrich Blank
7. Role of macrophages in renal injury, repair and regeneration
Vincent Lee, Qi Cao, Yiping Wang and David C.H. Harris
8. T-cells contribution to regenerative processes
Hamid Rabb
STEM CELLS IN REGENERATIVE PROCESSES
9. MSC and reparative processes
Benjamin D. Humphreys and John V. Bonventre
10. Stem cells in regenerative processes: Endothelial progenitor cells and the kidney
Matthieu Monge, Anton J. van Zonneveld and Ton J. Rabelink
11. The potential of the side population in regenerative nephrology
Melissa H. Little and G. A. Challen
12. Very small embryonic like stem cells (VSELs) and their potential relevance for kidney homeostasis
Dong-Myung Shin, Rui Liu, Janina Ratajczak, Magda Kucia and Mariusz Z. Ratajczak
13. Stem Cells in Regenerative Processes; Induced Pluripotent Stem Cells
Kenji Osafune and Shinya Yamanaka
14. Methods of Isolation and Culture of Adult Stem cells
Lindolfo da Silva Meirelles and Nance Beyer Nardi
STEM CELLS - FROM THE NICHE TO REPAIR
15. Stem cell niche in the kidney
Laura Lasagni, Elena Lazzeri and Paola Romagnani
16. Creation of artificial niches
Glenn D. Prestwich, Tammer Ghaly, Philip Brudnicki, Brian Ratliff and Michael S. Goligorsky
17. Imaging of transplanted and native stem cells
Xiang-Yang Zhu, Martin Rodriguez-Porcel and Lilach O. Lerman
CAUSES OF REGENERATIVE FAILURE
16. Stem cell injury and premature senescence
Michael S. Goligorsky
17. Regeneration and Aging: Regulation by Sirtuins and the NAD+ Salvage Pathway
Nica M. Borradaile, Alanna Watson, and J. Geoffrey Pickering
18. Bone marrow-mesenchymal stem cells in organ repair and strategies to optimize their efficacy
Christodoulos Xinaris, Barbara Imberti, Giuseppe Remuzzi and Marina Morigi
EMERGING CLINICAL ASPECTS OF STEM CELL THERAPY
19. Treatment of Acute Kidney Injury with allogeneic Mesenchymal Stem Cells: Preclinical and initial Clinical Data
Florian E. Toegel and Christof Westenfelder
20. Clinical trials in Renal Regenerative Medicine
Maarten B. Rookmaaker, Jaap A. Joles and Marianne C. Verhaar
21. Potential risks of stem cell therapies
Uta Kunter and Juergen Floege
22. Tissue engineering in urology
Anthony Atala
23. Ethical issues in SC therapy
Donald W. Landry
24. Stem Cell Banking
Vicente Mirabet and Pilar Solves
