Vitamin D

INTRODUCTION CH 1: Historical Perspective SECTION I: CHEMISTRY, METABOLISM, AND CIRCULATION CH 2: Vitamin D Metabolism CH 3: Photobiology of Vitamin D CH 4: The Vitamin D-25 Hydroxylase CH 5: The 25-Hydroxyvitamin D 1-alpha-Hydroxylase CH 6: The 25-Hydroxyvitamin D 24-Hydroxylase CH 7: Mutant Mouse Models of Vitamin D Metabolic Enzymes CH 8: Vitamin D Binding Protein CH 9: New Aspects of DBP CH 10: Endocytic Pathways for 25-(OH) Vitamin D3 SECTION II: MECHANISM OF ACTION CH 11: The Vitamin D Receptor CH 12: Vitamin D Receptor Promoter and Regulation of Receptor Expression CH 13: Nuclear Vitamin D Receptor: Structure-Function, Molecular Control of Gene Transcription, and Novel Bioactions CH 14: Vitamin D Receptor Cofactors: Function, Regulation, and Selectivity CH 15: VDR LBD Crystal Structures CH 16: Comodulators of VDR-Mediated: Gene Expression CH 17: Promoter Targeting of VDR Through A Chromatin Remodeling Complex CH 18: Molecular Basis of the Diversity of Vitamin D Target Genes CH 19: Intranuclear Organization of the Regulatory Machinery for Vitamin D-Mediated Control of Skeletal Gene CH 20: Mouse Models of Vitamin D Receptor Ablation CH 21: Intranuclear Vitamin D Response Element Binding CH 22: VDR and RXR Subcellular Trafficking CH 23: 1a,25(OH)2-vitamin D3 mediated rapid and genomic responses are dependent upon critical structure-function relationships for both the ligand and receptor(s) SECTION III: MINERAL HOMEOSTASIS CH 24: Vitamin D and the Intestinal Absorption of Calcium: A View and Overview CH 25: Intestinal Calcium Absorption: Lessons from Knock Out Mice and Men CH 26: Phosphate Homeostasis CH 27: Mineralization CH 28: Modeling and Remodeling: How Bone Cells Work Together CH 29: Vitamin D and the Kidney CH 30: Vitamin D and the Parathyroids CH 31: Calcium-Sensing Receptor SECTION IV: TARGET ORGANS AND ACTIONS: A. Organs/Tissues CH 32: Bone CH 33: Cartilage and Vitamin D: Genomic and Nongenomic Regulation CH 34: Dento-Alveolar Bone Complex and Vitamin D CH 35: Role in Skin and Hair CH 36: Regulation of Immune Responses by Vitamin D Receptor Ligands CH 37: Osteoblasts CH 38: Vitamin D and Osteoclastogenesis CH 39: Vitamin D Control of the Calcitonin Gene in Thyroid C Cells CH 40: Vitamin D Regulation of Type I Collagen Expression in Bone CH 41: Target Genes: Bone Proteins CH 42: The Calbindins: Calbindin-D9k and Calbindin-D28k CH 43: Target Genes CH 44: Effects of 1,25-Dihydroxyvitamin D3 on Voltage-Sensitive Calcium Channels in the Vitamin D Endocrine System CH 45: Vitamin D and the Cellular Response to Oxidative Stress SECTION V: HUMAN PHYSIOLOGY CH 46: Vitamin D: Role in the Calcium Economy CH 47: Effects of Race, Geography, Body Habitus, Diet, and Exercise on Vitamin D Metabolism CH 48: Perinatal Vitamin D Actions CH 49: Vitamin D Deficiency and Calcium Absorption During Infancy and Childhood CH 50: Vitamin D Metabolism and Aging CH 51: Vitamin D Metabolism in Pregnancy and Lactation CH 52: Vitamin D and Reproductive Organs CH 53: Vitamin D Receptor as a Sensor for Toxic Bile Acids CH 54: The Renin-Angiotensin System CH 55: Vitamin D and Muscle CH 56: Vitamin D and Cardiovascular Medicine SECTION VI: DIAGNOSIS AND MANAGEMENT CH 57: Approach to the Patient with Metabolic Bone Disease CH 58: Detection of Vitamin D and Its Major Metabolites CH 59: Bone Histomorphometry CH 60: Radiology of Rickets and Osteomalacia CH 61: The Pharmacology of Vitamin D, Including Fortification Strategies SECTION VII: DISORDERS OF THE VITAMIN D: ENDOCRINE SYSTEM CH 62: How to Define Normal Values for Serum Concentrations of 25-Hydroxyvitamin D? An Overview CH 63: Vitamin D and the Pathogenesis of Rickets and Osteomalacia CH 64: The Hypocalcemic Disorders: Differential Diagnosis and Therapeutic Use of Vitamin D CH 65: Vitamin D Deficiency and Nutritional Rickets in Children CH 66: Vitamin D Insufficiency in Adults and the Elderly CH 67: Vitamin D and Osteoporosis CH 68: Genetic Vitamin D Receptor Polymorphisms and Risk of CH 69: Clinical Disorders of Phosphate Homeostasis CH 70: Disorders of Phosphate Metabolism: Autosomal Dominant Hypophosphatemic Rickets, Tumor Induced Osteomalacia, Fibrous Dysplasia, and the Pathophysiological Relevance of FGF23 TIO, ADDR FGF-23 CH 71: Vitamin D Pseudodeficiency CH 72: Hereditary 1,25-Dihydroxyvitamin D Resistant Rickets CH 73: Glucocorticoids and Vitamin D CH 74: Drug and Hormone Effects on Vitamin D Metabolism CH 75: Bone Disorders Associated with Gastrointestinal & Hepatobiliary Disease CH 76: Vitamin D and Renal Failure CH 77: Idiopathic Hypercalciuria and Nephrolithiasis CH 78: Hypercalcemia Due to Vitamin D Toxicity CH 79: Extra-renal 1'-hydroxylase Activity and Human Disease SECTION VIII: NEW VITAMIN D ANALOGS CH 80: Overview: Rational Design of 1a,25-Dihydroxyvitamin D3 Analogs (Deltanoids) CH 81: Analog Metabolism CH 82: Mechanisms for the Selective Actions of Vitamin D Analogs CH 83: Molecular Basis for Differential Action of Vitamin D Analogs CH 84: Development of New Vitamin D Analogs CH 85: Geminis: The 1,25-dihydroxy Vitamin D Analogs with Two Side-Chains CH 86: Development of OCT and ED-71 CH 87: 2-Carbon-Modified Analogs of 19-Nor- 1a,25-Dihydroxyvitamin D3 CH 88: Non-steroidal Analogs SECTION IX: VITAMIN D AND CANCER CH 89: Vitamin D: Cancer and Differentiation CH 90: Vitamin D, Sunlight, and the Natural History of Prostate Cancer CH 91: Epidemiology of Cancer Risk: Vitamin D and Calcium CH 92: Differentiation and the Cell Cycle CH 93: Vitamin D and Breast Cancer CH 94: Vitamin D and Prostate Cancer CH 95: Vitamin D and Colon Cancer CH 96: Vitamin D and Hematological: Malignancy CH 97: Clinical Development of Calcitriol and Calcitriol Analogs in Oncology: Progress and Considerations for Future Development SECTION X: EMERGING USES: Overview: Vitamin D Vs. Calcium Effects CH 98: Vitamin D3: Autoimmunity and Immunosuppression CH 99: Vitamin D and Diabetes CH 100: Vitamin D, A Neuroactive Hormone: From Brain Development to Neurodegenerative Disorders CH 101: Psoriasis and Other Skin Diseases CH 102: Muscles and Falls CH 103: Renal Failure and Secondary Hyperparathyroidism CH 104: Inhibition of Benign Prostatic Hyperplasia by Vitamin D Receptor Ligands